• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?

作者信息

Levinson Douglas F, Mostafavi Sara, Milaneschi Yuri, Rivera Margarita, Ripke Stephan, Wray Naomi R, Sullivan Patrick F

机构信息

Departments of Psychiatry and Behavioral Sciences Stanford University, Stanford, California..

Departments of Computer Science Stanford University, Stanford, California.

出版信息

Biol Psychiatry. 2014 Oct 1;76(7):510-2. doi: 10.1016/j.biopsych.2014.07.029.

DOI:10.1016/j.biopsych.2014.07.029
PMID:25201436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4740915/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4593/4740915/702b0f4337b5/nihms754944f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4593/4740915/702b0f4337b5/nihms754944f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4593/4740915/702b0f4337b5/nihms754944f1.jpg

相似文献

1
Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?重度抑郁症的遗传学研究:为何尚无全基因组关联研究结果以及我们对此能做些什么?
Biol Psychiatry. 2014 Oct 1;76(7):510-2. doi: 10.1016/j.biopsych.2014.07.029.
2
Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder.全基因组拷贝数变异、验证和筛查研究提示一种新的拷贝数多态性与重度抑郁症自杀未遂有关。
Gene. 2020 Sep 10;755:144901. doi: 10.1016/j.gene.2020.144901. Epub 2020 Jun 15.
3
Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts.全基因组范围内罕见短缺失的负担在四大队列的重度抑郁症中得到富集。
Biol Psychiatry. 2019 Jun 15;85(12):1065-1073. doi: 10.1016/j.biopsych.2019.02.022. Epub 2019 Mar 13.
4
Common variants in the BCL9 gene conferring risk of schizophrenia.BCL9基因中的常见变异赋予精神分裂症风险。
Arch Gen Psychiatry. 2011 Mar;68(3):232-40. doi: 10.1001/archgenpsychiatry.2011.1.
5
Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder.PCLO作为重度抑郁症相关基因的全基因组显著性
Twin Res Hum Genet. 2017 Aug;20(4):267-270. doi: 10.1017/thg.2017.30. Epub 2017 May 25.
6
Copy Number Variations in Neuropsychiatric Disorders.神经精神疾病中的拷贝数变异。
Int J Mol Sci. 2023 Sep 5;24(18):13671. doi: 10.3390/ijms241813671.
7
Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms.估计所有单核苷酸多态性导致的重度抑郁症的遗传方差。
Biol Psychiatry. 2012 Oct 15;72(8):707-9. doi: 10.1016/j.biopsych.2012.03.011. Epub 2012 Apr 19.
8
A haplotype of glycogen synthase kinase 3β is associated with early onset of unipolar major depression.糖原合酶激酶 3β 的单倍型与单相重度抑郁症的早发性有关。
Genes Brain Behav. 2010 Oct;9(7):799-807. doi: 10.1111/j.1601-183X.2010.00617.x. Epub 2010 Aug 4.
9
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.通过发病年龄分层进行的全基因组关联研究:精神基因组学联盟重度抑郁症工作组
Biol Psychiatry. 2017 Feb 15;81(4):325-335. doi: 10.1016/j.biopsych.2016.05.010. Epub 2016 May 24.
10
Investigation of copy number variation in subjects with major depression based on whole-genome sequencing data.基于全基因组测序数据的重度抑郁症患者拷贝数变异研究。
J Affect Disord. 2017 Oct 1;220:38-42. doi: 10.1016/j.jad.2017.05.044. Epub 2017 May 30.

引用本文的文献

1
Polygenic scores for depression are associated with indices of neighborhood adversity.抑郁症的多基因评分与邻里逆境指标相关。
J Psychopathol Clin Sci. 2025 Aug 21. doi: 10.1037/abn0001038.
2
Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression.抑郁症中HHV-6再激活与SLC6A3(C>T,rs40184)、BDNF(C>T,rs6265)及JARID2(G>A,rs9383046)单核苷酸多态性的关联
Biomed Rep. 2024 Oct 3;21(6):181. doi: 10.3892/br.2024.1869. eCollection 2024 Dec.
3
The genetics of severe depression.

本文引用的文献

1
Biological insights from 108 schizophrenia-associated genetic loci.108 个精神分裂症相关遗传位点的生物学见解。
Nature. 2014 Jul 24;511(7510):421-7. doi: 10.1038/nature13595. Epub 2014 Jul 22.
2
The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases.表型和遗传异质性对复杂疾病全基因组关联研究结果的影响。
PLoS One. 2013 Oct 11;8(10):e76295. doi: 10.1371/journal.pone.0076295. eCollection 2013.
3
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
重度抑郁症的遗传学
Mol Psychiatry. 2025 Mar;30(3):1117-1126. doi: 10.1038/s41380-024-02731-1. Epub 2024 Oct 15.
4
The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals.犬类饲养的遗传结构:97552 名欧洲血统个体的全基因组关联研究的大规模研究。
G3 (Bethesda). 2024 Aug 7;14(8). doi: 10.1093/g3journal/jkae116.
5
Identification of a strong genetic risk factor for major depressive disorder in the human virome.人类病毒组中一种重度抑郁症的强遗传风险因素的鉴定。
iScience. 2024 Feb 10;27(3):109203. doi: 10.1016/j.isci.2024.109203. eCollection 2024 Mar 15.
6
Evaluating 17 methods incorporating biological function with GWAS summary statistics to accelerate discovery demonstrates a tradeoff between high sensitivity and high positive predictive value.评估 17 种结合生物功能与 GWAS 汇总统计数据的方法以加速发现,结果表明高灵敏度和高阳性预测值之间存在权衡。
Commun Biol. 2023 Nov 24;6(1):1199. doi: 10.1038/s42003-023-05413-w.
7
Exome-wide association study of treatment-resistant depression suggests novel treatment targets.外显子组全基因组关联研究提示治疗抵抗性抑郁症的新治疗靶点。
Sci Rep. 2023 Aug 1;13(1):12467. doi: 10.1038/s41598-023-38984-z.
8
The Role of Sex in Genetic Association Studies of Depression.性别在抑郁症基因关联研究中的作用。
J Psychiatr Brain Sci. 2022;7(6). doi: 10.20900/jpbs.20220013. Epub 2022 Dec 30.
9
Gene Expression has Distinct Associations with Brain Structure and Function in Major Depressive Disorder.基因表达与重度抑郁症的大脑结构和功能有明显关联。
Adv Sci (Weinh). 2023 Mar;10(7):e2205486. doi: 10.1002/advs.202205486. Epub 2023 Jan 13.
10
Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples.精神分裂症和重度抑郁症的多基因风险评分与两个英国社区样本中的逆境社会经济指标相关。
Transl Psychiatry. 2022 Nov 14;12(1):477. doi: 10.1038/s41398-022-02247-8.
基于全基因组 SNP 估算的五种精神障碍的遗传关系。
Nat Genet. 2013 Sep;45(9):984-94. doi: 10.1038/ng.2711. Epub 2013 Aug 11.
4
The power of meta-analysis in genome-wide association studies.荟萃分析在全基因组关联研究中的作用。
Annu Rev Genomics Hum Genet. 2013;14:441-65. doi: 10.1146/annurev-genom-091212-153520. Epub 2013 May 24.
5
A mega-analysis of genome-wide association studies for major depressive disorder.一项针对重度抑郁症的全基因组关联研究的 mega 分析。
Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3.
6
Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes.基于全基因组基因型估计遗传相关时诊断分类错误的影响。
Eur J Hum Genet. 2012 Jun;20(6):668-74. doi: 10.1038/ejhg.2011.257. Epub 2012 Jan 18.
7
Genome-wide association study identifies five new schizophrenia loci.全基因组关联研究确定了五个新的精神分裂症易感基因位点。
Nat Genet. 2011 Sep 18;43(10):969-76. doi: 10.1038/ng.940.
8
Common SNPs explain a large proportion of the heritability for human height.常见的单核苷酸多态性解释了人类身高遗传的很大一部分。
Nat Genet. 2010 Jul;42(7):565-9. doi: 10.1038/ng.608. Epub 2010 Jun 20.
9
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.常见的多基因变异会增加患精神分裂症和双相情感障碍的风险。
Nature. 2009 Aug 6;460(7256):748-52. doi: 10.1038/nature08185. Epub 2009 Jul 1.
10
The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women.男性和女性常见精神疾病及物质使用障碍的遗传和环境风险因素结构。
Arch Gen Psychiatry. 2003 Sep;60(9):929-37. doi: 10.1001/archpsyc.60.9.929.