Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?
作者信息
Levinson Douglas F, Mostafavi Sara, Milaneschi Yuri, Rivera Margarita, Ripke Stephan, Wray Naomi R, Sullivan Patrick F
机构信息
Departments of Psychiatry and Behavioral Sciences Stanford University, Stanford, California..
Departments of Computer Science Stanford University, Stanford, California.
出版信息
Biol Psychiatry. 2014 Oct 1;76(7):510-2. doi: 10.1016/j.biopsych.2014.07.029.
Abstract
摘要
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Biological insights from 108 schizophrenia-associated genetic loci.108 个精神分裂症相关遗传位点的生物学见解。
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Genome-wide association study identifies five new schizophrenia loci.全基因组关联研究确定了五个新的精神分裂症易感基因位点。
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Common SNPs explain a large proportion of the heritability for human height.常见的单核苷酸多态性解释了人类身高遗传的很大一部分。
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.常见的多基因变异会增加患精神分裂症和双相情感障碍的风险。
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