Worm M, Lippert U, Geier J, Schnuch A
Klinik für Dermatologie, Venerologie und Allergologie, Allergie-Centrum-Charité, Charité-Universitätsmedizin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Deutschland.
Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen, Deutschland.
Hautarzt. 2015 Sep;66(9):646-51. doi: 10.1007/s00105-015-3675-0.
Allergic contact eczema in children is frequent. If clinically suspected, a patch test should be performed. In the present study, data obtained from 116,742 patients who had undergone a patch test from 2005-2014 were analysed. The children group (range 0-12 years) included 925 patients. If at least 700 tested individuals were considered, the most frequent sensitizations in this group were nickel sulfate (8.5 %), fragrance mix I (5.5 %), and colophony (3.4 %), whereby sensitisation in adults was higher for nickel sulfate (15.5 %) and fragrance mix 1 (8.4 %), while being similar for colophony (3.7 %). In adolescents with and without a profession, nickel sulfate (11.1 and 13.6 %, respectively) and cobalt (II) chloride (3.9 and 3.4 %, respectively) were the most frequent positively tested contact allergens. Sensitisations toward fragrance mix I was low (3.9 and 3.4 %, respectively) in comparison to the adult group (8.4 %). In both children and adolescents, toluene diamine and paraphenylenediamine sensitizations were not infrequent, but it must be considered that these allergens were only tested if suspected. The data show that the sensitisation profile among children and adolescents display patterns similar to those in adults. Sensitisations in childhood and adolescence towards dyes like paraphenylendiamine may be associated with increased use of tattooing in these groups.
儿童过敏性接触性湿疹很常见。如果临床上怀疑,应进行斑贴试验。在本研究中,分析了2005年至2014年接受斑贴试验的116742名患者的数据。儿童组(年龄范围0至12岁)包括925名患者。如果考虑至少700名受试个体,该组中最常见的致敏原是硫酸镍(8.5%)、香料混合物I(5.5%)和松香(3.4%),其中硫酸镍(15.5%)和香料混合物1(8.4%)在成人中的致敏率更高,而松香的致敏率(3.7%)相似。在有职业和无职业的青少年中,硫酸镍(分别为11.1%和13.6%)和氯化钴(II)(分别为3.9%和3.4%)是最常见的阳性接触过敏原。与成人组(8.4%)相比,对香料混合物I的致敏率较低(分别为3.9%和3.4%)。在儿童和青少年中,甲苯二胺和对苯二胺致敏并不罕见,但必须考虑到这些过敏原仅在怀疑时才进行检测。数据表明,儿童和青少年的致敏情况与成人相似。儿童和青少年对诸如对苯二胺等染料的致敏可能与这些群体中纹身使用的增加有关。