Houkin K, Nakada T, Suzuki N, Kwee I L
Neurochemistry Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553.
Magn Reson Med. 1989 Dec;12(3):364-8. doi: 10.1002/mrm.1910120308.
A method for obtaining nuclear magnetic resonance (NMR) spectroscopic signals confined to the cerebral cortex in rat using a cortical coil constructed based on the principles of the zig-zag coil is described. We obtained 31P NMR spectra of normal cerebral cortex and cold-induced injured cortex using this cortical coil. The cortical coil clearly demonstrated an increase in inorganic phosphate (Pi) confirmed to cerebral cortex which, by contrast, the conventional planar surface coil failed to detect. There are significant metabolic differences between cortex and subcortical tissues. The technique described here, capable of assessing cortical metabolism in vivo without contamination by the underlying tissue, has substantial application to studies of cerebral metabolism.
描述了一种使用基于曲折线圈原理构建的皮质线圈在大鼠中获取局限于大脑皮质的核磁共振（NMR）光谱信号的方法。我们使用这种皮质线圈获得了正常大脑皮质和冷诱导损伤皮质的31P NMR光谱。皮质线圈清楚地显示出大脑皮质中无机磷酸盐（Pi）增加，相比之下，传统的平面表面线圈未能检测到。皮质和皮质下组织之间存在显著的代谢差异。这里描述的技术能够在不被下层组织污染的情况下体内评估皮质代谢，在脑代谢研究中有大量应用。
