一种用于磷-31光谱分析的新型双面线圈方法：大鼠半球脑损伤的研究。

A novel double-surface coil approach to phosphorus-31 spectroscopy: a study of hemispheric brain injury in the rat.

作者信息

Chew W M, Moseley M E, Nishimura M C, Hashimoto T, Pitts L H, James T L

机构信息

Department of Pharmaceutical Chemistry, University of California, San Francisco 94143.

出版信息

Magn Reson Med. 1985 Dec;2(6):567-75. doi: 10.1002/mrm.1910020607.

DOI:10.1002/mrm.1910020607

PMID:3880098

Abstract

An arrangement of two surface coils was devised to allow phosphorus-31 (31P) NMR spectroscopy of a localized hemispheric brain injury model in the rat. Two elliptical (8 X 12 mm) surface coils are placed parallel to each other (3 mm apart) over each side of the rat head. Spectra are collected from either the normal or the injured side of the head using the appropriate surface coil. A passive detuning method was used to eliminate unwanted coil-coil interactions. 31P imaging results with the two coils on phantoms show excellent isolation (6% signal overlap) between the two coils. The two-coil setup was then used to follow a time course of injury from the hemispheric injury model.

摘要

设计了一种双表面线圈装置，用于对大鼠局部半球脑损伤模型进行磷-31（31P）核磁共振波谱分析。两个椭圆形（8×12毫米）表面线圈彼此平行放置（相距3毫米）在大鼠头部两侧。使用合适的表面线圈从头部的正常侧或损伤侧采集波谱。采用被动失谐方法消除不需要的线圈间相互作用。在体模上使用这两个线圈进行31P成像的结果显示，两个线圈之间具有出色的隔离效果（信号重叠率为6%）。然后使用双线圈装置跟踪半球损伤模型的损伤时间进程。