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[电离辐射作用下骨髓成纤维细胞集落形成单位系统中储备群体细胞组成的分析]

[An analysis of the cell composition of the reserve population in the colony-forming unit system of bone marrow fibroblasts under the action of ionizing radiation].

作者信息

Kovrigina A M, Gruzdev G P

出版信息

Patol Fiziol Eksp Ter. 1989 Nov-Dec(6):18-20.

PMID:2628874
Abstract

The system of stromal cell precursors--colony-forming units of fibroblasts (CFUf) of the bone marrow possesses a significant reserve population which is mobilized in exposure to extreme effects, after irradiation in the given case. This compensatory-adaptational reaction is evidently one of the factors of optimization of postradiation hematopoiesis restoration. Analysis of the cell composition of the CFUf reserve population showed that it does not differ basically from the population tested under normal conditions. Differences are also noted, however: two CFUf pools are distinguished in the reserve population distinctly which possess the largest cell reserve--in the region of the small and large clones.

摘要

骨髓基质细胞前体系统——成纤维细胞集落形成单位(CFUf)拥有大量储备细胞群,在受到极端影响时(如在本病例中受到辐射后)会被动员起来。这种代偿适应性反应显然是辐射后造血恢复优化的因素之一。对CFUf储备细胞群的细胞组成分析表明,它与正常条件下检测的细胞群基本没有差异。然而,也注意到了一些差异:在储备细胞群中明显区分出两个CFUf池,它们在小克隆和大克隆区域拥有最大的细胞储备。

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