黄芩苷对肠道病毒71型的体外抗病毒作用
The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro.
作者信息
Li Xiang, Liu Yuanyuan, Wu Tingting, Jin Yue, Cheng Jianpin, Wan Changbiao, Qian Weihe, Xing Fei, Shi Weifeng
机构信息
Department of Clinical Laboratory, Huai'an Hospital Affiliated of Xuzhou Medical College, 62 Huaihai south road, Huai'an, Jiangsu 223300, China.
Department of Clinical Laboratory, the Third Affiliated Hospital of Soochow University, 185 Juqian street, Changzhou, Jiangsu 213003, China.
出版信息
Viruses. 2015 Aug 19;7(8):4756-71. doi: 10.3390/v7082841.
Baicalin is a flavonoid compound extracted from Scutellaria roots that has been reported to possess antibacterial, anti-inflammatory, and antiviral activities. However, the antiviral effect of baicalin on enterovirus 71 (EV71) is still unknown. In this study, we found that baicalin showed inhibitory activity on EV71 infection and was independent of direct virucidal or prophylactic effect and inhibitory viral absorption. The expressions of EV71/3D mRNA and polymerase were significantly blocked by baicalin treatment at early stages of EV71 infection. In addition, baicalin could decrease the expressions of FasL and caspase-3, as well as inhibit the apoptosis of EV71-infected human embryonal rhabdomyosarcoma (RD) cells. Altogether, these results indicate that baicalin exhibits potent antiviral effect on EV71 infection, probably through inhibiting EV71/3D polymerase expression and Fas/FasL signaling pathways.
黄芩苷是从黄芩根中提取的一种黄酮类化合物，据报道具有抗菌、抗炎和抗病毒活性。然而，黄芩苷对肠道病毒71型（EV71）的抗病毒作用仍不清楚。在本研究中，我们发现黄芩苷对EV71感染具有抑制活性，且与直接杀病毒或预防作用以及抑制病毒吸附无关。在EV71感染的早期阶段，黄芩苷处理可显著阻断EV71/3D mRNA和聚合酶的表达。此外，黄芩苷可降低FasL和caspase-3的表达，并抑制EV71感染的人胚胎横纹肌肉瘤（RD）细胞的凋亡。总之，这些结果表明黄芩苷对EV71感染具有强大的抗病毒作用，可能是通过抑制EV71/3D聚合酶表达和Fas/FasL信号通路实现的。
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