Stevenson D K, Vreman H J, Ferguson J E, Lenert L A, Leonard M B, Gale R
Department of Pediatrics, Stanford University School of Medicine, California 94305.
Ann N Y Acad Sci. 1989;570:352-7. doi: 10.1111/j.1749-6632.1989.tb14934.x.
We conclude that 5 mg/kg of vitamin E, administered intra-arterially as an 8-hour continuous infusion, significantly and predictably raises serum vitamin E levels into the supraphysiologic range with no apparent side effects. In a group of premature infants whose initial serum vitamin E levels were generally greater than or equal to 0.5 mg/dL, no decrease in bilirubin production was observed. Thus, vitamin E deficiency probably does not play a prominent role in jaundice of prematurity.
我们得出结论，以8小时持续输注的方式动脉内给予5mg/kg的维生素E，可显著且可预测地将血清维生素E水平提高到超生理范围，且无明显副作用。在一组初始血清维生素E水平通常大于或等于0.5mg/dL的早产儿中，未观察到胆红素生成减少。因此，维生素E缺乏可能在早产儿黄疸中不起主要作用。
