Chen Liming, Chen Yu
Clin Lab. 2015;61(7):653-60. doi: 10.7754/clin.lab.2014.141124.
Coagulation testing is widely applied clinically, and laboratories increasingly demand automated coagulation analyzers with short turn-around times and high-throughput. The purpose of this study was to evaluate the performance of the Sysmex CS-5100 automated coagulation analyzer for routine use in a clinical laboratory.
The prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (Fbg), and D-dimer were compared between the Sysmex CS-5100 and Sysmex CA-7000 analyzers, and the imprecision, comparison, throughput, STAT function, and performance for abnormal samples were measured in each.
The within-run and between-run coefficients of variation (CV) for the PT, APTT, INR, and D-dimer analyses showed excellent results both in the normal and pathologic ranges. The correlation coefficients between the Sysmex CS-5100 and Sysmex CA-7000 were highly correlated. The throughput of the Sysmex CS-5100 was faster than that of the Sysmex CA-7000. There was no interference at all by total bilirubin concentrations and triglyceride concentrations in the Sysmex CS-5100 analyzer.
We demonstrated that the Sysmex CS-5100 performs with satisfactory imprecision and is well suited for coagulation analysis in laboratories processing large sample numbers and icteric and lipemic samples.
凝血检测在临床上广泛应用，实验室对周转时间短和高通量的自动凝血分析仪的需求日益增加。本研究的目的是评估Sysmex CS - 5100自动凝血分析仪在临床实验室常规使用中的性能。
比较了Sysmex CS - 5100和Sysmex CA - 7000分析仪之间的凝血酶原时间（PT）、国际标准化比值（INR）、活化部分凝血活酶时间（APTT）、纤维蛋白原（Fbg）和D - 二聚体，并分别测量了两者的不精密度、可比性、通量、急诊功能以及对异常样本的性能。
PT、APTT、INR和D - 二聚体分析的批内和批间变异系数（CV）在正常和病理范围内均显示出优异的结果。Sysmex CS - 5100和Sysmex CA - 7000之间的相关系数高度相关。Sysmex CS - 5100的通量比Sysmex CA - 7000更快。Sysmex CS - 5100分析仪中总胆红素浓度和甘油三酯浓度均无干扰。
我们证明了Sysmex CS - 5100具有令人满意的不精密度，非常适合处理大量样本以及黄疸和脂血样本的实验室进行凝血分析。
