Buckley Peter F, Miller Brian J
Medical College of Georgia, Georgia Regents University, 1120 15th Street, AA-1006, Augusta, GA 30912, USA.
Department of Psychiatry, Georgia Regents University, 1120 15th Street, AA-1006, Augusta, GA 30912, USA.
Psychiatr Clin North Am. 2015 Sep;38(3):373-7. doi: 10.1016/j.psc.2015.05.001. Epub 2015 Jun 23.
This overview highlights the current hot topics in schizophrenia research. One major drawback to progress is the ability to define and focus on the right patient group. Schizophrenia is a biased and heterogeneous (group of) condition(s), the boundaries of which remain uncertain. An initiative that will focus attention away from (mere) symptoms of the illness and toward its underlying neurobiological construct(s) is the Research Domain Criteria. A preliminary analysis from a large neurobiological study suggests that 3 distinct biological phenotypes underlie the clinical expression of 1 major psychosis. A firmer neurobiologically based foundation is needed to advance this field.
本综述突出了精神分裂症研究当前的热点话题。进展的一个主要障碍是定义并聚焦于正确患者群体的能力。精神分裂症是一种有偏向性且异质性的病症，其界限仍不明确。“研究领域标准”是一项将注意力从疾病的（单纯）症状转向其潜在神经生物学结构的倡议。一项大型神经生物学研究的初步分析表明，1种主要精神病的临床表型有3种不同的生物学基础。该领域的发展需要更坚实的基于神经生物学的基础。
