Sulpher Jeffrey, Mathur Shrey, Lenihan Daniel, Johnson Christopher, Turek Michele, Law Angeline, Stadnick Ellamae, Dattilo Franco, Graham Nadine, Dent Susan F
The Ottawa Hospital Cancer Centre, University of Ottawa, Ottawa, ON, Canada K1H 8L6.
Vanderbilt Heart and Vascular Institute, Nashville, TN 37232, USA.
J Oncol. 2015;2015:391848. doi: 10.1155/2015/391848. Epub 2015 Aug 2.
Cardiotoxicity is the second leading cause of morbidity and mortality in cancer survivors. The objective of this international cardiac oncology survey was to gain a better understanding of current knowledge and practice patterns among HCPs involved in the management of cancer patients exposed to potentially cardiotoxic drugs. Between 2012 and 2013, we conducted an email-based survey of HCPs involved in the management of cardiac disease in cancer patients. 393 survey responses were received, of which 77 were from Canadian respondents. The majority of respondents were cardiologists (47%), followed closely by medical oncologists. The majority of respondents agreed that cardiac issues are important to cancer patients (97%). However, only 36% of total respondents agreed with an accepted definition of cardiotoxicity. While 78% of respondents felt that cardiac medications are protective during active cancer treatment, only 51% would consider prescribing these medications up-front in cancer patients. Although results confirm a high level of concern for cardiac safety, there continues to be a lack of consensus on the definition of cardiotoxicity and a discrepancy in clinical practice between cardiologists and oncologists. These differences in opinion require resolution through more effective research collaboration and formulation of evidence-based guidelines.
心脏毒性是癌症幸存者发病和死亡的第二大主要原因。这项国际心脏肿瘤学调查的目的是更好地了解参与管理接受潜在心脏毒性药物治疗的癌症患者的医疗保健人员(HCPs)的现有知识和实践模式。在2012年至2013年期间,我们对参与癌症患者心脏疾病管理的医疗保健人员进行了一项基于电子邮件的调查。共收到393份调查问卷回复,其中77份来自加拿大受访者。大多数受访者是心脏病专家(47%),紧随其后的是肿瘤内科医生。大多数受访者一致认为心脏问题对癌症患者很重要(97%)。然而,只有36%的受访者认同心脏毒性的公认定义。虽然78%的受访者认为心脏药物在积极的癌症治疗期间具有保护作用,但只有51%的人会考虑在癌症患者中预先开具这些药物。尽管结果证实了对心脏安全性的高度关注,但在心脏毒性的定义上仍然缺乏共识,心脏病专家和肿瘤内科医生在临床实践中也存在差异。这些意见分歧需要通过更有效的研究合作和制定循证指南来解决。