Dunmire Barbrina, Harper Jonathan D, Cunitz Bryan W, Lee Franklin C, Hsi Ryan, Liu Ziyue, Bailey Michael R, Sorensen Mathew D
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Department of Urology, University of Washington School of Medicine, Seattle, Washington.
J Urol. 2016 Jan;195(1):171-7. doi: 10.1016/j.juro.2015.05.111. Epub 2015 Aug 22.
Ultrasound is known to overestimate kidney stone size. We explored measuring the acoustic shadow behind kidney stones combined with different ultrasound imaging modalities to improve stone sizing accuracy.
A total of 45 calcium oxalate monohydrate stones were imaged in vitro at 3 different depths with the 3 different ultrasound imaging modalities of conventional ray line, spatial compound and harmonic imaging. The width of the stone and the width of the acoustic shadow were measured by 4 operators blinded to the true size of the stone.
Average error between the measured and true stone width was 1.4 ± 0.8 mm, 1.7 ± 0.9 mm, 0.9 ± 0.8 mm for ray line, spatial compound and harmonic imaging, respectively. Average error between the shadow width and true stone width was 0.2 ± 0.7 mm, 0.4 ± 0.7 mm and 0.0 ± 0.8 mm for ray line, spatial compound and harmonic imaging, respectively. Sizing error based on the stone width worsened with greater depth (p <0.001) while the sizing error based on the shadow width was independent of depth.
Shadow width was a more accurate measure of true stone size than a direct measurement of the stone in the ultrasound image (p <0.0001). The ultrasound imaging modality also impacted the measurement accuracy. All methods performed similarly for shadow size while harmonic imaging was the most accurate stone size modality. Overall 78% of the shadow sizes were accurate to within 1 mm, which is similar to the resolution obtained with clinical computerized tomography.
已知超声会高估肾结石大小。我们探索了结合不同超声成像模式测量肾结石后方的声影,以提高结石大小测量的准确性。
使用传统射线、空间复合成像和谐波成像这三种不同的超声成像模式,对45颗一水草酸钙结石在体外3个不同深度进行成像。由4名对结石真实大小不知情的操作人员测量结石宽度和声影宽度。
对于射线成像、空间复合成像和谐波成像,测量的结石宽度与真实结石宽度之间的平均误差分别为1.4±0.8毫米、1.7±0.9毫米、0.9±0.8毫米。对于射线成像、空间复合成像和谐波成像,声影宽度与真实结石宽度之间的平均误差分别为0.2±0.7毫米、0.4±0.7毫米、0.0±0.8毫米。基于结石宽度的大小测量误差随深度增加而恶化(p<0.001),而基于声影宽度的大小测量误差与深度无关。
声影宽度比超声图像中对结石的直接测量更能准确反映真实结石大小(p<0.0001)。超声成像模式也会影响测量准确性。所有方法在声影大小测量方面表现相似,而谐波成像是最准确的结石大小测量模式。总体而言,78%的声影大小测量误差在1毫米以内,这与临床计算机断层扫描获得的分辨率相似。