Brines J, Hernández R
An Esp Pediatr. 1978 Feb;11(2):97-112.
The response of blood and kidney to orally administered CaCl2 (4.1 mEq. X Kg.) in a short acid loading was compared to that attained with standard agent NH4Cl (3.9 mEq. X Kg) in two groups of normal infants through a 6 hrs. period. Plasma pH and bicarbonate decreased significantly. Minimum urine pH was 5.0 o lesser in all infants. Decrease of urine pH was greater to CaCl2 than to NH4Cl group but the net hydrogen ion excretion by the kidney was minor. Accordingly this experience CaCl2 can replace NH4Cl as acidifying substance in a short acid loading test. Indication will be diffuse hepatic lesions rendering dangerous NH4Cl administration.
在两组正常婴儿中,通过6小时的短时间酸负荷,比较口服氯化钙(4.1毫当量×千克)和标准试剂氯化铵(3.9毫当量×千克)时血液和肾脏的反应。血浆pH值和碳酸氢盐显著下降。所有婴儿的最低尿pH值均低于5.0。氯化钙组尿pH值的下降幅度大于氯化铵组,但肾脏净氢离子排泄量较少。因此,在短时间酸负荷试验中,氯化钙可替代氯化铵作为酸化物质。适应症为弥漫性肝脏病变,使氯化铵给药具有危险性。