Rao Mangala, Xavier Denis, Devi Padmini, Sigamani Alben, Faruqui Atiya, Gupta Rajeev, Kerkar Prafulla, Jain Rajendra Kumar, Joshi Rajnish, Chidambaram N, Rao Daya Sagar, Thanikachalam S, Iyengar S S, Verghese Kiron, Mohan V, Pais Prem
Department of Pharmacology, St. John's Medical College, Bangalore, India; Division of Clinical Research and Training, St. John's Research Institute, Bangalore, India.
Professor and Head, Department of Pharmacology, St. John's Medical College, Bangalore, India; Coordinator, Division of Clinical Research and Training, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
Indian Heart J. 2015 Jul-Aug;67(4):302-10. doi: 10.1016/j.ihj.2015.05.003. Epub 2015 Jul 10.
To conduct a systematic review on the prevalence, risk factors, treatments and outcomes of Coronary Artery Disease (CAD) in Indians.
We conducted a systematic review of studies in Indians with CAD from Jan 1969 to Oct 2012. Initial search yielded 3885 studies and after review 288 observational studies were included. The prevalence of CAD in urban areas was 2.5%-12.6% and in rural areas, 1.4%-4.6%. The prevalence of risk factors was: smoking (8.9-40.5%), hypertension (13.1-36.9%) and diabetes mellitus (0.2-24.0%). The median time to reach hospital after an MI was 360 min. In hospital rates of drug use were: antiplatelets 68%-97.9%, beta blockers 47.3%-65.8% and ACEIs 27.8-56.8%.
In this first systematic review of CAD in India, prevalence of risk factors is high, treatments delayed and use of evidence based treatments variable.
对印度人冠状动脉疾病（CAD）的患病率、危险因素、治疗方法及预后进行系统评价。
我们对1969年1月至2012年10月期间有关印度CAD患者的研究进行了系统评价。初步检索得到3885项研究，经筛选后纳入288项观察性研究。CAD在城市地区的患病率为2.5%-12.6%，在农村地区为1.4%-4.6%。危险因素的患病率分别为：吸烟（8.9-40.5%）、高血压（13.1-36.9%）和糖尿病（0.2-24.0%）。心肌梗死后到达医院的中位时间为360分钟。住院期间药物使用率分别为：抗血小板药物68%-97.9%、β受体阻滞剂47.3%-65.8%和血管紧张素转换酶抑制剂27.8%-56.8%。
在印度首次对CAD进行的系统评价中，危险因素患病率高，治疗延迟，循证治疗的使用情况不一。
