Edahiro T, Ohta N, Matsuoka H, Ishii A, Tanizaki Y, Kitani H, Kunitomi T, Noono S, Tachibana K
Department of Parasitology, Okayama University Medical School.
Jpn J Med Sci Biol. 1989 Jun;42(3):101-10. doi: 10.7883/yoken1952.42.101.
Chironomid antigens are currently one of the important allergens for bronchial asthma in Japan. We evaluated in vitro responses of peripheral blood lymphocytes (PBLs) to chironomid antigens and compared these responses with serum IgE levels. PBLs from adult asthmatic patients showed stronger proliferation in response to the extract of adult midges of Chironomus yoshimatsui compared with healthy adults. On the other hand, elevated PBL responses of child asthmatic patients to chironomid antigens were not observed. There was no significant correlation between PBL proliferation and the serum IgE level. Our results might suggest that elevated PBL proliferation in response to chironomid allergens has somehow important pathogenic roles in adult cases although this does not correlate directly with specific IgE production.
摇蚊抗原目前是日本支气管哮喘的重要过敏原之一。我们评估了外周血淋巴细胞（PBLs）对摇蚊抗原的体外反应，并将这些反应与血清IgE水平进行了比较。与健康成年人相比，成年哮喘患者的PBLs对吉松摇蚊成虫提取物的反应表现出更强的增殖。另一方面，未观察到儿童哮喘患者对摇蚊抗原的PBL反应升高。PBL增殖与血清IgE水平之间无显著相关性。我们的结果可能表明，尽管这与特异性IgE产生没有直接关联，但对摇蚊过敏原的PBL增殖升高在成人病例中具有某种重要的致病作用。
