Mihara B
Keio J Med. 1989 Dec;38(4):419-31. doi: 10.2302/kjm.38.419.
Abnormalities in the central cholinergic system have been reported in Alzheimer disease. The present study was designed to evaluate the effects of the central cholinergic neurons in the substantia innominata on cognitive functions and cerebral metabolism in rats. Forty-nine Wistar rats were trained for an active avoidance task for 5 days. On Day 5, rats which had acquired the avoidance response were divided into two groups. The lesioned group (n = 7) received ibotenic acid in the substantia innominata bilaterally and the sham-operated group (n = 7) received the vehicle only. From Day 8 to 12, the rats were again trained for the avoidance task. On Day 12, the local cerebral metabolic rate for glucose was measured by the 14C-2-deoxyglucose method. The rats in the lesioned group revealed severe deficits in retention and re-acquisition of the active avoidance task. In addition, the glucose metabolism was decreased in the cerebral cortices, especially in the frontal cortex (p less than 0.05). The central cholinergic neurons of the substantia innominata may be closely related to cognitive functions and to glucose metabolism in the cortices.
已有报道称阿尔茨海默病存在中枢胆碱能系统异常。本研究旨在评估无名质中中枢胆碱能神经元对大鼠认知功能和脑代谢的影响。49只Wistar大鼠接受了5天的主动回避任务训练。在第5天，已获得回避反应的大鼠被分为两组。损伤组（n = 7）双侧无名质注射鹅膏蕈氨酸，假手术组（n = 7）仅注射溶剂。从第8天到第12天，大鼠再次接受回避任务训练。在第12天，采用14C-2-脱氧葡萄糖法测量局部脑葡萄糖代谢率。损伤组大鼠在主动回避任务的保持和重新获得方面表现出严重缺陷。此外，大脑皮质尤其是额叶皮质的葡萄糖代谢降低（p < 0.05）。无名质的中枢胆碱能神经元可能与认知功能以及皮质中的葡萄糖代谢密切相关。
