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大鼠无名质-皮质胆碱能通路的γ-氨基丁酸能和阿片类调节

GABAergic and opioid regulation of the substantia nigra innominata-cortical cholinergic pathway in the rat.

作者信息

Wood P L, McQuade P S, Nair N P

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):789-92. doi: 10.1016/0278-5846(84)90060-5.

DOI:10.1016/0278-5846(84)90060-5
PMID:6099595
Abstract

The decrease in cortical acetylcholine turnover (TRACh) observed after parenteral GABA agonists is also replicated by local drug injections into the cholinergic cell body region, the substantia innominata. The decrement in cortical TRACh induced by opiates and opioid peptides is not replicated by local drug injections into the substantia innominata. These data indicate that the cholinergic cell bodies of the substantia innominata receive a direct inhibitory GABAergic input while opioid regulatory influences are not at the level of the cell bodies of these cholinergic neurons.

摘要

经肠胃外给予GABA激动剂后观察到的皮质乙酰胆碱周转率(TRACh)下降,也可通过向胆碱能细胞体区域无名质局部注射药物来复制。阿片类药物和阿片肽诱导的皮质TRACh下降,不能通过向无名质局部注射药物来复制。这些数据表明,无名质的胆碱能细胞体接受直接的抑制性GABA能输入,而阿片类药物的调节作用不在这些胆碱能神经元细胞体水平。

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