Yao Jia-Lu, Sun Si-Jia, Zhou Ya-Feng, Xu Lang-Biao, Yang Xiang-Jun, Qian Xiao-Dong
Department of Cardiology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
Int J Clin Exp Med. 2015 Jun 15;8(6):8767-75. eCollection 2015.
To investigate the relationship between angiotensinogen (AGT) gene M235T polymorphism and hypertrophic cardiomyopathy (HCM) to explore the potential role of the AGT polymorphism in HCM.
PubMed, Embase, OVID, Cochrane library, CNKI, Wan Fang Database were searched to identify the studies involving AGT M235T polymorphism and HCM. Two authors performed independent literature review and study quality assessment using the Newcastle-Ottawa Scale (NOS) checklist. A random-effects model was used to calculate the overall combined risk estimates.
Nine studies involving 887 cases and 1407 controls were included in our meta-analysis. No significant associations were found between AGT M235T polymorphism and HCM (allele model T vs M: OR = 1.17, 95% CI = 0.95-1.45; dominant model TT vs (MM/MT): OR = 1.21, 95% CI = 1.00-1.45; recessive model (TT/MT) vs MM: OR = 1.12, 95% CI = 0.87-1.45; heterozygous comparison MT vs MM: OR = 1.07, 95% CI = 0.82-1.41; homozygous comparison TT vs MM OR = 1.19, 95% CI = 0.88-1.61. In subgroup analysis, the significant difference of association between AGT M235T polymorphism and HCM existed in Asian and sporadic hypertrophic cardiomyopathy (SHCM), but no significant difference was found in Europeans and familial hypertrophic cardiomyopathy (FHCM).
There is no association between AGT M235T polymorphism and HCM in general populations, but such a relationship exists in Asians and SHCM.
研究血管紧张素原（AGT）基因M235T多态性与肥厚型心肌病（HCM）之间的关系，以探讨AGT多态性在HCM中的潜在作用。
检索PubMed、Embase、OVID、Cochrane图书馆、中国知网、万方数据库，以识别涉及AGT M235T多态性和HCM的研究。两位作者使用纽卡斯尔-渥太华量表（NOS）清单进行独立的文献综述和研究质量评估。采用随机效应模型计算总体合并风险估计值。
我们的荟萃分析纳入了9项研究，共887例病例和1407例对照。未发现AGT M235T多态性与HCM之间存在显著关联（等位基因模型T与M：OR = 1.17，95%CI = 0.95 - 1.45；显性模型TT与（MM/MT）：OR = 1.21，95%CI = 1.00 - 1.45；隐性模型（TT/MT）与MM：OR = 1.12，95%CI = 0.87 - 1.45；杂合子比较MT与MM：OR = 1.07，95%CI = 0.82 - 1.41；纯合子比较TT与MM：OR = 1.19，95%CI = 0.88 - 1.61）。在亚组分析中，AGT M235T多态性与HCM之间关联的显著差异存在于亚洲人和散发性肥厚型心肌病（SHCM）中，但在欧洲人和家族性肥厚型心肌病（FHCM）中未发现显著差异。
在一般人群中，AGT M235T多态性与HCM之间无关联，但在亚洲人和SHCM中存在这种关系。
