自体干细胞疗法：衰老和慢性疾病如何影响干细胞和祖细胞。
Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells.
作者信息
Efimenko Anastasia Yu, Kochegura Tatiana N, Akopyan Zhanna A, Parfyonova Yelena V
机构信息
Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University , Moscow, Russian Federation .
Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University , Moscow, Russian Federation . ; Laboratory of Angiogenesis, Russian Cardiology Research and Production Complex , Moscow, Russian Federation .
出版信息
Biores Open Access. 2015 Jan 1;4(1):26-38. doi: 10.1089/biores.2014.0042. eCollection 2015.
During recent years different types of adult stem/progenitor cells have been successfully applied for the treatment of many pathologies, including cardiovascular diseases. The regenerative potential of these cells is considered to be due to their high proliferation and differentiation capacities, paracrine activity, and immunologic privilege. However, therapeutic efficacy of the autologous stem/progenitor cells for most clinical applications remains modest, possibly because of the attenuation of their regenerative potential in aged patients with chronic diseases such as cardiovascular diseases and metabolic disorders. In this review we will discuss the risk factors affecting the therapeutic potential of adult stem/progenitor cells as well as the main approaches to mitigating them using the methods of regenerative medicine.
近年来，不同类型的成体干/祖细胞已成功应用于多种疾病的治疗，包括心血管疾病。这些细胞的再生潜力被认为归因于它们的高增殖和分化能力、旁分泌活性以及免疫特权。然而，自体干/祖细胞在大多数临床应用中的治疗效果仍然有限，这可能是因为在患有心血管疾病和代谢紊乱等慢性疾病的老年患者中，它们的再生潜力有所减弱。在这篇综述中，我们将讨论影响成体干/祖细胞治疗潜力的风险因素，以及使用再生医学方法减轻这些因素的主要途径。
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