Campisi Judith, Robert Ladislas
Buck Institute for Research on Aging, Novato, Calif., USA.
Interdiscip Top Gerontol. 2014;39:45-61. doi: 10.1159/000358899. Epub 2014 May 13.
Cell senescence is one of the major paradigms of aging research. It started with the demonstration by L. Hayflick of the limited number of divisions by normal, nontransformed cells, not shown by transformed malignant cells, this processes being largely regulated by the telomere-telomerase system. A complete renewal of this discipline came from the demonstration that cells can enter senescence at any time by an anti-oncogene-triggered pathway, enabling them to escape malignancy. The senescent cell became a major actor of the aging process, among others, by the acquisition of the senescence-associated secretory phenotype. This chapter is devoted to the regulatory process involved in the acquisition of the senescent cell phenotype and its role in organismal aging.
细胞衰老现象是衰老研究的主要范例之一。它始于L. 海弗利克所证实的正常非转化细胞的分裂次数有限，而转化的恶性细胞则不会出现这种情况，这一过程在很大程度上受端粒 - 端粒酶系统调控。该学科的一次全面革新源于一项证明，即细胞可通过由抗癌基因触发的途径在任何时候进入衰老状态，从而使其能够避免发生恶性病变。衰老细胞通过获得衰老相关分泌表型等方式，成为衰老过程中的一个主要因素。本章将致力于探讨衰老细胞表型获得过程中所涉及的调控机制及其在机体衰老中的作用。
