Huang Ching-Wen, Tsai Hsiang-Lin, Huang Ming-Yii, Huang Chun-Ming, Yeh Yung-Sung, Ma Cheng-Jen, Wang Jaw-Yuan
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Surgery, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
World J Surg Oncol. 2015 Aug 28;13:257. doi: 10.1186/s12957-015-0640-4.
We evaluated the clinicopathologic features and outcomes of Taiwanese patients with right-sided versus left-sided colon cancer according to various cancer stages.
A total of 1095 patients with primary colorectal cancer (CRC) undergoing surgery at a single-institution were enrolled. We analyzed patient differences in terms of clinicopathologic features, overall survival (OS) and cancer-specific survival (CSS) of right- versus left-sided colon cancer.
Right-sided colon cancers were noted in 249 (22.7%) patients, and left-sided colon cancers were noted in 846 (77.3%) patients. Right-sided colon cancers were found to be significantly larger (P = 0.003) and poorly differentiated (P < 0.001), while also exhibiting advanced depth of tumor invasion (P = 0.002) and advanced UICC/AJCC stage (P = 0.016). Patients with right-sided colon cancers had both poorer OS and CSS than those with left-sided colon cancers (P = 0.021 and 0.023, respectively). However, analysis by various stages revealed significant OS and CSS differences (P = 0.002 and 0.002, respectively) between right-sided and left-sided colon cancers only in stage III patients.
This study demonstrated poorer OS and CSS in patients with right-sided versus those with left-sided colon cancers, but significant differences were noted only in stage III patients.
我们根据不同癌症分期评估了台湾右侧结肠癌患者与左侧结肠癌患者的临床病理特征及预后。
共纳入了1095例在单一机构接受手术的原发性结直肠癌（CRC）患者。我们分析了右侧结肠癌与左侧结肠癌患者在临床病理特征、总生存期（OS）和癌症特异性生存期（CSS）方面的差异。
249例（22.7%）患者为右侧结肠癌，846例（77.3%）患者为左侧结肠癌。发现右侧结肠癌明显更大（P = 0.003）且分化程度低（P < 0.001），同时肿瘤浸润深度更深（P = 0.002）且UICC/AJCC分期更晚（P = 0.016）。右侧结肠癌患者的OS和CSS均比左侧结肠癌患者差（分别为P = 0.021和0.023）。然而，按不同分期分析显示，仅在III期患者中，右侧结肠癌与左侧结肠癌之间的OS和CSS存在显著差异（分别为P = 0.002和0.002）。
本研究表明，右侧结肠癌患者的OS和CSS比左侧结肠癌患者差，但仅在III期患者中存在显著差异。
