Khamaisy Saker, Zuiderbaan Hendrik A, Thein Ran, Gladnick Brian P, Pearle Andrew D
Computer Assisted Surgery Center, Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 E. 70th Street, New York, NY, 10021, USA.
Skeletal Radiol. 2016 Jan;45(1):57-61. doi: 10.1007/s00256-015-2244-z. Epub 2015 Aug 28.
To analyze knees in varying stages of osteoarthritis (OA) for the presence of coronal tibiofemoral (CTF) subluxation and to determine if CTF subluxation severity is related to knee OA worsening.
We retrospectively evaluated CTF subluxation and limb alignment in 113 patients with different stages of knee OA who were being considered for an arthroplasty procedure. Knee OA was classified as "mild" or "severe" according to Kellgren-Lawrence scale. CTF subluxation was measured in the study groups and in 40 knees of healthy controls using software developed specifically on the basis of Iterative Closest Point mathematical algorithm.
Mean CTF subluxation in "mild OA" and "severe OA" groups was 3.5% (±2) and 3.5 % (±5) of the tibial plateau, respectively. For both the mild and severe OA groups, CTF subluxation was significantly increased compared to the 1.4% (±1) CTF subluxation in the control group, (p < 0.0001) and (p = 0.012), respectively. However, there was no significant difference in CTF subluxation between the mild OA and severe OA groups (p = 0.75). Limb varus malalignment in mild OA and severe OA groups was 3.6° (±2.2) and 5.3° (±2.6), respectively. Both significantly increased comparing to the 1° (±0.7) control group alignment (p < 0.0001). Varus malalignment in the severe OA group was significantly increased comparing to the mild OA group (p = 0.0003).
CTF subluxation is a radiographic finding related to knee OA which occurs mainly in the early stages of the osteoarthritic process and stagnates as OA progresses.
分析处于不同阶段骨关节炎（OA）的膝关节是否存在冠状位胫股（CTF）半脱位，并确定CTF半脱位的严重程度是否与膝关节OA的恶化相关。
我们回顾性评估了113例正在考虑进行关节置换手术的不同阶段膝关节OA患者的CTF半脱位和肢体对线情况。根据Kellgren-Lawrence量表将膝关节OA分为“轻度”或“重度”。使用专门基于迭代最近点数学算法开发的软件，在研究组和40例健康对照者的膝关节中测量CTF半脱位。
“轻度OA”组和“重度OA”组的平均CTF半脱位分别为胫骨平台的3.5%（±2）和3.5%（±5）。对于轻度和重度OA组，与对照组1.4%（±1）的CTF半脱位相比，CTF半脱位均显著增加，分别为（p < 0.0001）和（p = 0.012）。然而，轻度OA组和重度OA组之间的CTF半脱位无显著差异（p = 0.75）。轻度OA组和重度OA组的肢体内翻畸形分别为3.6°（±2.2）和5.3°（±2.6）。与对照组1°（±0.7）的对线相比，两者均显著增加（p < 0.0001）。重度OA组的内翻畸形与轻度OA组相比显著增加（p = 0.0003）。
CTF半脱位是一种与膝关节OA相关的影像学表现，主要发生在骨关节炎过程的早期阶段，并随着OA的进展而停滞。
