Huang Min, Chen Siyan, Liang Yubin, Guo Yi
Second Clinical College, Jinan University, No.1017 Dongmen North Road, Shenzhen, 518020, China.
Curr Top Med Chem. 2016;16(8):867-73. doi: 10.2174/1568026615666150827095433.
Dementia is an acquired progressive cognitive dysfunction, affecting the content of consciousness rather than the level of consciousness. Most dementia is senile dementia, accounting for the majority of dementia. The most important and common form of senile dementia is refractory dementia, which includes Alzheimer's disease (AD) and vascular dementia (VD). Due to the diversity and uncertainty of the pathogenic mechanism of VD and AD, no significantly effective drug currently exists. Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis that has a wide range of pharmacological effects. studies in recent years have also found that berberine can additionally treat senile dementia by affecting neurotransmitter, anti-oxidative stress, metabolism and other multi-target pathways. Multi-target treatment of senile dementia by berberine is a potential avenue of study for senile dementia treatment.
痴呆是一种获得性进行性认知功能障碍，影响意识内容而非意识水平。大多数痴呆是老年性痴呆，占痴呆的大多数。老年性痴呆最重要和最常见的形式是难治性痴呆，其中包括阿尔茨海默病（AD）和血管性痴呆（VD）。由于VD和AD致病机制的多样性和不确定性，目前尚无显著有效的药物。黄连素是从黄连中提取的一种天然异喹啉生物碱，具有广泛的药理作用。近年来的研究还发现，黄连素可通过影响神经递质、抗氧化应激、代谢等多靶点途径额外治疗老年性痴呆。黄连素对老年性痴呆的多靶点治疗是老年性痴呆治疗的一个潜在研究方向。
