Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Med Res Rev. 2021 May;41(3):1812-1834. doi: 10.1002/med.21778. Epub 2020 Dec 30.
Nowadays, human microbiome research is rapidly growing and emerging evidence has witnessed the critical role that oral microbiome plays in the process of human health and disease. Oral microbial dysbiosis has been confirmed as a contributory cause for diseases in multiple body systems, ranging from the oral cavity to the gastrointestinal, endocrine, immune, cardiovascular, and even nervous system. As research progressing, oral microbiome-based diagnosis and therapy are proposed and applied, which may represent potential drug targets in systemic diseases. Recent studies have uncovered the possible association between periodontal disease and prostatic disease, suggesting new prevention and therapeutic treatment for the disease by targeting periodontal pathogens. Thus, we performed this review to first explore the association between the oral microbiome and prostatic disease, according to current knowledge based on published articles, and then mainly focus on the underlying molecular and cellular mechanisms and the potential prevention and treatment derived from these mechanistic studies.
如今，人类微生物组研究正在迅速发展，越来越多的证据表明口腔微生物组在人类健康和疾病的过程中起着关键作用。口腔微生物失调已被证实是多种身体系统疾病的致病因素，从口腔到胃肠道、内分泌、免疫、心血管，甚至神经系统。随着研究的进展，基于口腔微生物组的诊断和治疗被提出并应用，这可能代表系统性疾病的潜在药物靶点。最近的研究揭示了牙周病和前列腺疾病之间可能存在的关联，这表明通过针对牙周病病原体，可以为该疾病提供新的预防和治疗方法。因此，我们进行了这项综述，首先根据已发表的文章，探讨了口腔微生物组与前列腺疾病之间的关联，然后主要关注这些机制研究得出的潜在分子和细胞机制以及潜在的预防和治疗方法。
