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毛囊黏蛋白沉积症:地方病流行区麻风病的重要鉴别诊断。

Follicular mucinosis: an important differential diagnosis of leprosy in an endemic area.

作者信息

Westphal Danielle Cristine, Pennini Silmara Navarro, Souza Petra Pereira de, Maquiné Gustavo Ávila, Schettini Antônio Pedro Mendes, Santos Mônica

机构信息

Fundação Alfredo da Matta, Manaus, AM, BR.

Secretaria Municipal de Sáude de Manaus, Manaus, AM, BR.

出版信息

An Bras Dermatol. 2015 May-Jun;90(3 Suppl 1):147-9. doi: 10.1590/abd1806-4841.20153450.

Abstract

Primary follicular mucinosis is a rare dermatosis characterized by the accumulation of mucin in the follicular epithelium and sebaceous glands. Clinically, it is characterized by the presence of papules or well-circumscribed and infiltrated plaques. In this paper, we report the case of a female patient, seven years old, evolving for three months with an asymptomatic, erythematous and infiltrated plaque located in the chin region. The research of thermal, pain and tactile sensitivity was inconclusive. Histological findings confirmed the diagnosis of follicular mucinosis. There was regression of the lesion with the use of medium potency topical corticosteroids for 20 days. The pathogenesis of follicular mucinosis remains unknown, being in some cases associated with lymphoproliferative disorders. In endemic areas of leprosy, isolated and infiltrated follicular mucinosis lesions should be further differentiated from leprosy.

摘要

原发性毛囊黏蛋白沉积症是一种罕见的皮肤病,其特征为毛囊上皮和皮脂腺中黏蛋白积聚。临床上,其特征为丘疹或边界清楚的浸润性斑块。在本文中,我们报告了一例7岁女性患者,其颏部出现无症状性红斑浸润性斑块3个月。温度觉、痛觉和触觉敏感性检查结果不明确。组织学检查结果确诊为毛囊黏蛋白沉积症。使用中效外用糖皮质激素治疗20天后皮损消退。毛囊黏蛋白沉积症的发病机制尚不清楚,在某些情况下与淋巴增生性疾病有关。在麻风病流行地区,孤立性浸润性毛囊黏蛋白沉积症皮损应与麻风病进一步鉴别。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4883/4540533/8c1d7448c311/abd-90-03-s1-0147-g01.jpg

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