Ma Han, Chen Meilan, Liu Junru, Li Ying, Li Juan
Sun Yat-sen University, Guangzhou, CN.
An Bras Dermatol. 2015 May-Jun;90(3 Suppl 1):209-11. doi: 10.1590/abd1806-4841.20153708.
Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin.
聚乙二醇化脂质体阿霉素是一种重要的抗肿瘤药物，对多种实体瘤具有活性。与阿霉素相比，它具有完全不同的药代动力学和毒性特征。它很少引起心脏毒性或脱发等副作用，但经常导致多种皮肤黏膜反应，包括手足红斑性感觉异常、弥漫性滤泡疹、擦烂样皮疹、黑素斑新形成、口腔炎和放射性回忆性皮炎。我们报告了1例罕见的多发性骨髓瘤患者，在接受1个疗程的聚乙二醇化脂质体阿霉素治疗后，立即出现严重的口腔炎和食管炎，并伴有轻微的手足红斑性感觉异常。
