Guerriero Kathryn A, Wilson Steven R, Boutagy Nabil E, Liu Chi, Sinusas Albert J, Zeiss Caroline J
Department of Comparative Medicine, Department of Medicine, Yale Translational Research Imaging Center, Yale University, New Haven, Connecticut.
Department of Comparative Medicine, Department of Medicine, Yale Translational Research Imaging Center, Yale University, New Haven, Connecticut;, Email:
Comp Med. 2018 Feb 1;68(1):56-62.
An adult female beagle (Canis lupus familiaris) used in a model of doxorubicin-induced cardiomyopathy presented with epithelial desquamation on the shoulders and ventrum after receiving the 8th weekly intravenous dose of the free form of doxorubicin (20 mg/m2; total accumulation, 160 mg/m2). The lesions were empirically treated with topical disinfectants and topical and systemic antibiotics. Despite treatment, the lesions progressed and ulcerated. Bacterial culture revealed Staphylococcus aureus, but trichogram, skin scraping, and fungal culture were negative for microorganisms. Skin biopsies revealed epidermal and apocrine gland hyperplasia, apocrine gland dilation, abnormal maturation of epithelial keratinocytes, and perivascular lymphocytic infiltration. These histopathologic findings resemble those in humans and canines after chronic administration of doxorubicin-containing pegylated liposomes. Here we report a clinical presentation after chronic administration of the free form of doxorubicin. In dogs, cutaneous toxicity after administration of pegylated liposomal doxorubicin is most often localized to the footpads, limbs, and axillary and urogenital regions. In the current case, lesions affected the ventrum and trunk but did not involve the footpads or axillary or urogenital regions.
一只成年雌性比格犬（犬属家犬）用于阿霉素诱导的心肌病模型，在每周静脉注射第8次游离形式的阿霉素（20mg/m²；总累积量，160mg/m²）后，肩部和腹部出现上皮脱屑。这些病变经验性地用局部消毒剂以及局部和全身抗生素治疗。尽管进行了治疗，病变仍进展并形成溃疡。细菌培养显示为金黄色葡萄球菌，但毛发检查、皮肤刮片和真菌培养均未发现微生物。皮肤活检显示表皮和顶泌汗腺增生、顶泌汗腺扩张、上皮角质形成细胞异常成熟以及血管周围淋巴细胞浸润。这些组织病理学发现与慢性给予含阿霉素的聚乙二醇化脂质体后人类和犬类的表现相似。在此我们报告慢性给予游离形式阿霉素后的临床表现。在犬类中，给予聚乙二醇化脂质体阿霉素后的皮肤毒性最常局限于脚垫、四肢以及腋窝和泌尿生殖区域。在当前病例中，病变影响腹部和躯干，但未累及脚垫或腋窝或泌尿生殖区域。
