Shen Peng-Xiang, Wang Xiao-Chen, Wang Peng, Zhu Ru-Yi, Yu Jin-Quan
Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
J Am Chem Soc. 2015 Sep 16;137(36):11574-7. doi: 10.1021/jacs.5b08914. Epub 2015 Sep 3.
2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.
2-甲氧羰基降冰片烯被确定为一种更有效的瞬态介质，可促进钯（II）催化的酰胺与各种烷基碘的间位C（sp(2)）-H烷基化反应，以及与先前不相容的芳基碘的芳基化反应。使用特制的喹啉配体对该反应的进行也至关重要。
