Pd(II)/降冰片烯催化的对甲苯磺酰基保护苯丙氨酸的间-C-H 烷基化反应。
Pd(II)/Norbornene-Catalyzed Meta-C-H Alkylation of Nosyl-Protected Phenylalanines.
机构信息
Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of Green Chemistry , Jiangxi Normal University , Nanchang , Jiangxi 330022 , P.R. of China.
出版信息
J Org Chem. 2018 Nov 2;83(21):13211-13216. doi: 10.1021/acs.joc.8b01933. Epub 2018 Oct 18.
A Pd/norbornene-catalyzed direct meta-alkylation of nosyl-protected phenylalanine derivatives with alkyl iodides is reported in moderate to good yields. The use of diisopropyl bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate is identified as a more suitable transient mediator. A simple pyridine ligand is also essential for this reaction to proceed. No racemization was observed in this meta-methylation reaction.
报道了一种 Pd/降冰片烯催化的、Nos 保护的苯丙氨酸衍生物与碘代烷烃的直接间位烷基化反应，产率中等至良好。发现二异丙基双环[2.2.1]庚-5-烯-2,3-二甲酸酯是一种更合适的瞬态介体。对于该反应的进行，一个简单的吡啶配体也是必不可少的。在这个间位甲基化反应中没有观察到外消旋化。
Zotero 插件