Cheng H A, Drinnan C T, Pleshko N, Fisher O Z
Department of Bioengineering, Temple University, 1947 N 12th Street, Philadelphia, PA, USA.
Soft Matter. 2015 Oct 21;11(39):7783-91. doi: 10.1039/c5sm01224d. Epub 2015 Aug 27.
Natural tannins are attractive as building blocks for biomaterials due to their antioxidant properties and ability to form interpolymer complexes (IPCs) with other macromolecules. One of the major challenges to tannin usage in biomedical applications is their instability at physiological conditions and a lack of control over the purity and reactivity. Herein, we report the synthesis and characterization of tannin-like polymers with controlled architecture, reactivity, and size. These pseudotannins were synthesized by substituting linear dextran chains with gallic, resorcylic, and protocatechuic pendant groups to mimic the structure of natural hydrolysable tannins. We demonstrate that these novel materials can self-assemble to form reductive and colloidally stable nanoscale and microscale particles. Specifically, the synthesis, turbidity, particle size, antioxidant power, and cell uptake of IPCs derived from pseudotannins and poly(ethylene glycol) was evaluated.
天然单宁作为生物材料的构建单元具有吸引力，这归因于其抗氧化特性以及与其他大分子形成聚合物间复合物（IPC）的能力。单宁在生物医学应用中使用的主要挑战之一是它们在生理条件下的不稳定性以及对纯度和反应性缺乏控制。在此，我们报告了具有可控结构、反应性和尺寸的类单宁聚合物的合成与表征。这些假单宁是通过用没食子酸、间苯二酚和原儿茶酸侧基取代线性葡聚糖链来模拟天然可水解单宁的结构而合成的。我们证明这些新型材料可以自组装形成具有还原性且胶体稳定的纳米级和微米级颗粒。具体而言，评估了源自假单宁和聚乙二醇的IPC的合成、浊度、粒径、抗氧化能力和细胞摄取情况。
