光学相干断层扫描血管造影在小儿视网膜疾病中的应用
Optical Coherence Tomography Angiography in Pediatric Retinal Disorders.
作者信息
Ponugoti Arathi, Baumal Caroline R, Vajzovic Lejla
机构信息
Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.
Department of Ophthalmology, New England Eye Center, Tufts University School of Medicine, Boston, MA, USA.
出版信息
J Vitreoretin Dis. 2022 Jun 3;6(3):221-228. doi: 10.1177/24741264221083873. eCollection 2022 May-Jun.
PURPOSE
The rapid and noninvasive nature of optical coherence tomography angiography (OCTA) makes it a potentially valuable tool for imaging the retina in children. With the optimization of tabletop systems and the development of experimental handheld OCTA devices, there is expanded potential for OCTA in the clinic and the operating room. This article reviews the utility of OCTA in some of the most common pediatric retinal disorders.
METHODS
A thorough computerized PubMed search was performed to review relevant published journal articles to contextualize and identify the role of OCTA in common retinal disorders with vascular involvement affecting children. Pertinent results and findings from original investigations and case reports were summarized.
RESULTS
The ability to quickly collect both qualitative and quantitative information about retinal microvasculature, in both the clinic and operating room settings, with OCTA, has led to the uncovering of microvascular features and morphologic changes in many pediatric retinal disorders such as Coats Disease, familial exudative vitreoretinopathy, incontinentia pigmenti, sickle cell retinopathy, Stargardt Disease, X-linked juvenile retinoschisis, retinopathy of prematurity, diabetic retinopathy in type 1 diabetes, pediatric retinal tumors, and choroidal neovascularization.
CONCLUSIONS
OCTA is a relevant tool to aid early detection, guide intervention, monitor treatment response, and understand pathogenesis in a number of pediatric retinal disorders.
目的
光学相干断层扫描血管造影（OCTA）快速且无创的特性使其成为儿童视网膜成像的潜在有价值工具。随着桌面系统的优化和实验性手持OCTA设备的发展，OCTA在临床和手术室中的应用潜力得到了扩展。本文综述了OCTA在一些最常见的儿童视网膜疾病中的应用。
方法
进行了全面的计算机化PubMed检索，以回顾相关已发表的期刊文章，从而将OCTA在影响儿童的伴有血管受累的常见视网膜疾病中的作用进行背景化并确定其作用。总结了原始研究和病例报告中的相关结果和发现。
结果
借助OCTA能够在临床和手术室环境中快速收集有关视网膜微血管系统的定性和定量信息，这使得人们发现了许多儿童视网膜疾病中的微血管特征和形态学变化，如科茨病、家族性渗出性玻璃体视网膜病变、色素失禁症、镰状细胞性视网膜病变、斯塔加特病、X连锁青少年视网膜劈裂症、早产儿视网膜病变、1型糖尿病中的糖尿病性视网膜病变、儿童视网膜肿瘤以及脉络膜新生血管形成。
结论
OCTA是有助于早期检测、指导干预、监测治疗反应以及了解多种儿童视网膜疾病发病机制的相关工具。
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