钯催化的烯基酚与甲酸苯酯的对映选择性氢酯化反应。一种合成光学活性二氢香豆素的简便方法。

A palladium-catalyzed enantioselective hydroesterification of alkenylphenols with phenyl formate. A facile approach to optically active dihydrocoumarins.

作者信息

Li Jingfu, Chang Wenju, Ren Wenlong, Liu Wei, Wang Haining, Shi Yian

机构信息

State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Chemistry for Life Sciences, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

出版信息

Org Biomol Chem. 2015 Nov 7;13(41):10341-7. doi: 10.1039/c5ob01431j.

DOI:10.1039/c5ob01431j

PMID:26313876

Abstract

An effective palladium-catalyzed enantioselective hydroesterification of alkenylphenols with phenyl formate as a CO source is described. A variety of optically active dihydrocoumarins can be obtained in generally high yields with up to 91% ee.

摘要

描述了一种有效的钯催化的对映选择性氢酯化反应，该反应以甲酸苯酯作为CO源，对烯基酚进行反应。可以以通常较高的产率获得多种光学活性二氢香豆素，对映体过量率高达91%。