Tsapanou Angeliki, Scarmeas Nikolaos, Gu Yian, Manly Jennifer, Schupf Nicole, Stern Yaakov, Barral Sandra
Cognitive Neuroscience Division, Department of Neurology and The Taub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA; Department of Social Medicine, Psychiatry and Neurology, National and Kapodistrian University of Athens, Athens, Greece.
Cognitive Neuroscience Division, Department of Neurology and The Taub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Social Medicine, Psychiatry and Neurology, National and Kapodistrian University of Athens, Athens, Greece.
Neurosci Lett. 2015 Oct 8;606:72-6. doi: 10.1016/j.neulet.2015.08.037. Epub 2015 Aug 24.
We aimed to examine the association between Apolipoprotein E (APOE) and sleep disturbances. This is a cross-sectional study, from the Washington Heights-Inwood Community Aging Project (WHICAP). A total of 1944 non-demented older adults took part in the study. Sleep dysfunction was measured using sleep categories derived from the Medical Outcomes Study Sleep Scale. Genetic association between APOE-ϵ4 genotype and sleep disturbances was assessed using unadjusted linear regression models. Secondary analyses were conducted adjusting for age, sex, education, ethnicity and body mass index (BMI). In the unadjusted model, individuals carrying the APOE-ϵ4 allele showed lower levels of snoring (β=-0.02, SE=0.01, p=0.010) and sleep apnea (β=-0.01, SE=0.01, p=0.037) when compared to non-ϵ4 carriers. After covariates' adjustment, ϵ4 carriers demonstrated stronger association with lower levels of both snoring (β=-0.02, SE=0.01, p=0.006), and sleep apnea (β=-0.01, SE=0.01, p=0.018). Our results suggest that APOE-ϵ4 is associated with decreased problems in snoring and sleep apnea, in non-demented older adults.
我们旨在研究载脂蛋白E（APOE）与睡眠障碍之间的关联。这是一项来自华盛顿高地-因伍德社区老龄化项目（WHICAP）的横断面研究。共有1944名非痴呆老年人参与了该研究。睡眠功能障碍通过医学结局研究睡眠量表得出的睡眠类别进行测量。使用未调整的线性回归模型评估APOE-ε4基因型与睡眠障碍之间的基因关联。进行了二次分析，对年龄、性别、教育程度、种族和体重指数（BMI）进行了调整。在未调整的模型中，与非ε4携带者相比，携带APOE-ε4等位基因的个体打鼾（β=-0.02，标准误=0.01，p=0.010）和睡眠呼吸暂停（β=-0.01，标准误=0.01，p=0.037）的水平较低。在对协变量进行调整后，ε4携带者与较低水平的打鼾（β=-0.02，标准误=0.01，p=0.006）和睡眠呼吸暂停（β=-0.01，标准误=0.01，p=0.018）之间表现出更强的关联。我们的结果表明，在非痴呆老年人中，APOE-ε4与打鼾和睡眠呼吸暂停问题的减少有关。
