Tan Shuping, Zou Yizhuang, Wykes Til, Reeder Clare, Zhu Xiaolin, Yang Fude, Zhao Yanli, Tan Yunlong, Fan Fengmei, Zhou Dongfeng
Institute of Mental Health, Peking University, China; Center of Psychiatry Research, Beijing Huilongguan Hospital, Beijing 100096, China.
Center of Psychiatry Research, Beijing Huilongguan Hospital, Beijing 100096, China.
Neurosci Lett. 2016 Jul 28;626:106-11. doi: 10.1016/j.neulet.2015.08.036. Epub 2015 Aug 24.
Individual-level cognitive remediation therapy (CRT) has been shown to be effective for cognitive improvement and social function amelioration. Here, we aimed to test the efficacy of group-based CRT in Chinese subjects with schizophrenia. One-hundred and four inpatients were randomly assigned to either 40 sessions of small-group CRT therapy or therapeutic contact-matched Musical and Dancing Therapy (MDT). Cognitive and social functioning, as well as clinical symptoms, were evaluated over the course of treatment. Specifically, cognitive function was evaluated using a battery of cognitive measurements, clinical symptoms were evaluated using the Positive and Negative Syndrome Scale, and social function was evaluated using the Nurse's Observation Scale for Inpatient Evaluation-30. All patients were evaluated pre- and post-treatment. Forty-four individuals in the CRT group and 46 in the MDT group completed all of the planned treatments and analyses. Cognitive functions, especially cognitive flexibility and memory, showed significant improvement in the CRT group over the course of the study. The MDT group also showed improvement in several cognitive flexibility assessments, but the degree of improvement was significantly greater in the CRT group. Several social-function factors exhibited a significant improvement in the CRT group, but not in the MDT group. Cognitive function improvement correlated positively with social function without predicting social function change. We conclude that group-based CRT is an effective and promising therapy.
个体水平的认知康复治疗（CRT）已被证明对认知改善和社会功能改善有效。在此，我们旨在测试基于小组的CRT对中国精神分裂症患者的疗效。104名住院患者被随机分配到40节小组CRT治疗或治疗性接触匹配的音乐与舞蹈治疗（MDT）中。在治疗过程中评估认知和社会功能以及临床症状。具体而言，使用一系列认知测量评估认知功能，使用阳性和阴性症状量表评估临床症状，使用护士住院患者评估观察量表-30评估社会功能。所有患者在治疗前后均接受评估。CRT组的44名个体和MDT组的46名个体完成了所有计划的治疗和分析。在研究过程中，CRT组的认知功能，尤其是认知灵活性和记忆力有显著改善。MDT组在几项认知灵活性评估中也有改善，但CRT组的改善程度明显更大。CRT组的几个社会功能因素有显著改善，而MDT组则没有。认知功能改善与社会功能呈正相关，但不能预测社会功能变化。我们得出结论，基于小组的CRT是一种有效且有前景的治疗方法。
