Evans Alana, Leishman Shaneen J, Walsh Laurence J, Seow W Kim
Centre for Paediatric Dentistry, University of Queensland, Brisbane, Australia.
Pediatr Dent. 2015 Jul-Aug;37(4):332-8.
The purpose of this study was to compare the effects of combinations of sodium fluoride and antiseptic compounds on the growth of Streptococcus mutans, Streptococcus sanguinis, and Lactobacillus acidophilus.
The agar diffusion assay was used to determine bacterial growth inhibition.
Of the combinations tested, 0.1 percent sodium fluoride and five percent povidone iodine produced synergistic antibacterial effects against S. mutans and S. sanguinis. The combination of 10 percent povidone iodine and 0.5 percent sodium hypochlorite produced additive antibacterial effects against L. acidophilus. Interference was seen in some combinations such as 0.01 percent chlorhexidine and 0.25 percent sodium lauryl sulphate, 0.5 percent sodium hypochlorite and 10 percent povidone iodine, and 0.01 percent cetyl pyridium chloride and 0.1 percent sodium fluoride. However, 0.1 percent sodium fluoride combined with 0.01 percent chlorhexidine did not interfere with the antibacterial effects of chlorhexidine against S. mutans or S. sanguinis.
Combinations of common antiseptics and fluoride compounds can produce interference, synergistic, or additive effects. The combination of 0.1 percent sodium fluoride and five percent povidone iodine had the greatest potential for suppression of S. mutans.
本研究旨在比较氟化钠与抗菌化合物组合对变形链球菌、血链球菌和嗜酸乳杆菌生长的影响。
采用琼脂扩散试验测定细菌生长抑制情况。
在所测试的组合中，0.1%的氟化钠与5%的聚维酮碘对变形链球菌和血链球菌产生协同抗菌作用。10%的聚维酮碘与0.5%的次氯酸钠组合对嗜酸乳杆菌产生相加抗菌作用。在一些组合中观察到干扰现象。如0.01%的洗必泰与0.25%的十二烷基硫酸钠、0.5%的次氯酸钠与10%的聚维酮碘以及0.01%的西吡氯铵与0.1%的氟化钠。然而，0.1%的氟化钠与0.01%的洗必泰组合并不干扰洗必泰对变形链球菌或血链球菌的抗菌作用。
常见抗菌剂与氟化物化合物的组合可产生干扰、协同或相加作用。0.1%的氟化钠与5%的聚维酮碘组合对抑制变形链球菌具有最大潜力。
