Rugge Massimo
Surgical Pathology & Cytopathology Unit, Department of Medicine - DIMED, University of Padova, Via Aristide Gabelli, 61, Padova 35121, Italy.
Gastroenterol Clin North Am. 2015 Sep;44(3):609-24. doi: 10.1016/j.gtc.2015.05.009. Epub 2015 Jul 7.
As Helicobacter pylori is a first-class carcinogen, eradication of the infection would be expected to be a beneficial measure for the (primary) prevention of gastric cancer. Given the natural history of gastric cancer, it is plausible that eradication before gastric atrophy sets in offers the best chance for cancer risk reduction. The beneficial effects of eradication may, nevertheless, still be achievable in more advanced disease. The reversibility of inflammatory lesions has been supported by undeniable evidence; the regression of mucosal atrophy/metaplasia has also been confirmed by several recent histologic studies.
由于幽门螺杆菌是一级致癌物，根除该感染有望成为（原发性）预防胃癌的一项有益措施。鉴于胃癌的自然病程，在胃萎缩出现之前进行根除可能为降低癌症风险提供最佳机会。然而，在更晚期的疾病中，根除的有益效果可能仍然可以实现。炎症性病变的可逆性已得到确凿证据的支持；黏膜萎缩/化生的消退也已被最近的几项组织学研究所证实。
