ten Bokum E M, van de Oever H L A, Radstake D W S, Arbouw M E L
Department of Clinical Pharmacy, Deventer Hospital, Deventer, the Netherlands.
Neth J Med. 2015 Aug;73(7):345-7.
We report on a patient on clozapine treatment who was admitted to our hospital with pneumonia. He had stopped smoking a few weeks before admission. The serum clozapine rose to a toxic level, most likely due to the combination of infection and smoking cessation. Physicians and pharmacists are often not aware of risk factors for decreased metabolism of clozapine.
我们报告了一名接受氯氮平治疗的患者，他因肺炎入住我院。入院前几周他已戒烟。血清氯氮平升至中毒水平，很可能是感染和戒烟共同作用的结果。医生和药剂师常常不了解氯氮平代谢降低的危险因素。
