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作为生物活性来源的咪唑并吡啶及其药理潜力——药物和植物材料中其含量的红外和拉曼光谱证据。

Imidazopyridines as a source of biological activity and their pharmacological potentials-Infrared and Raman spectroscopic evidence of their content in pharmaceuticals and plant materials.

作者信息

Dymińska Lucyna

机构信息

Department of Bioorganic Chemistry, Institute of Chemistry and Food Technology, Faculty of Engineering and Economics, Wrocław University of Economics, 118/120 Komandorska, 53-345 Wrocław, Poland.

出版信息

Bioorg Med Chem. 2015 Sep 15;23(18):6087-99. doi: 10.1016/j.bmc.2015.07.045. Epub 2015 Jul 29.

Abstract

Derivatives of imidazopyridine are used in medicinal chemistry due to their biological and pharmaceutical properties. This review article presents imidazopyridine pharmacological activity as antiinflammatory, anticancer, antiviral, antiosteoporotic, antiparasitic, and antihypertensive agents by studying its various synthesized derivatives. Some of compounds with imidazopyridine skeleton are used in psychiatry and autoimmune disorders. The presented data suggest that IR and Raman spectra measurements are a good methods for identification and characterization of the compounds containing imidazopyridine core. Two stretching vibrations: νas(Φ) and νs(Φ) are of a diagnostic importance. The appearance of these bands in the IR and Raman spectra of some plants, tissues and pharmaceuticals confirms the presence of imidazopyridine skeleton in these substances.

摘要

由于其生物学和药学特性,咪唑并吡啶衍生物在药物化学中得到应用。本文通过研究咪唑并吡啶的各种合成衍生物,阐述了其作为抗炎、抗癌、抗病毒、抗骨质疏松、抗寄生虫和抗高血压药物的药理活性。一些具有咪唑并吡啶骨架的化合物用于精神病学和自身免疫性疾病。所提供的数据表明,红外光谱和拉曼光谱测量是鉴定和表征含咪唑并吡啶核心化合物的良好方法。两种伸缩振动:νas(Φ)和νs(Φ)具有诊断重要性。这些谱带在一些植物、组织和药物的红外光谱和拉曼光谱中的出现证实了这些物质中存在咪唑并吡啶骨架。

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