Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy.
作者信息
Corrales Leticia, Gajewski Thomas F
机构信息
Department of Pathology, The University of Chicago, Chicago, IL, USA.
Department of Pathology, The University of Chicago, Chicago, IL, USA; Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, USA.
出版信息
Cytokine. 2016 Jan;77:245-7. doi: 10.1016/j.cyto.2015.08.258. Epub 2015 Aug 24.
Abstract
摘要
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本文引用的文献
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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.肿瘤微环境中STING的直接激活导致强效且全身性的肿瘤消退和免疫。
Cell Rep. 2015 May 19;11(7):1018-30. doi: 10.1016/j.celrep.2015.04.031. Epub 2015 May 7.
2
Immune checkpoint blockade: a common denominator approach to cancer therapy.免疫检查点阻断：癌症治疗的一种通用方法。
Cancer Cell. 2015 Apr 13;27(4):450-61. doi: 10.1016/j.ccell.2015.03.001. Epub 2015 Apr 6.
3
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.依赖于STING的胞质DNA传感促进免疫原性肿瘤中辐射诱导的I型干扰素依赖性抗肿瘤免疫。
Immunity. 2014 Nov 20;41(5):843-52. doi: 10.1016/j.immuni.2014.10.019. Epub 2014 Nov 6.
4
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.依赖于干扰素基因刺激蛋白（STING）的胞质DNA传感介导免疫原性肿瘤的固有免疫识别。
Immunity. 2014 Nov 20;41(5):830-42. doi: 10.1016/j.immuni.2014.10.017. Epub 2014 Nov 5.
5
Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment.基于克服肿瘤微环境内障碍的癌症免疫治疗策略。
Curr Opin Immunol. 2013 Apr;25(2):268-76. doi: 10.1016/j.coi.2013.02.009. Epub 2013 Apr 8.
6
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.环鸟苷酸-腺苷酸合酶是一种胞质 DNA 传感器，可激活 I 型干扰素途径。
Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20.
7
Type I interferon is selectively required by dendritic cells for immune rejection of tumors.Ⅰ型干扰素通过树突状细胞选择性地需要用于免疫排斥肿瘤。
J Exp Med. 2011 Sep 26;208(10):1989-2003. doi: 10.1084/jem.20101158. Epub 2011 Sep 19.
8
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.宿主 I 型干扰素信号通过 CD8α+树突状细胞对于抗肿瘤 CD8+T 细胞应答是必需的。
J Exp Med. 2011 Sep 26;208(10):2005-16. doi: 10.1084/jem.20101159. Epub 2011 Sep 19.
9
The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity.放疗的疗效依赖于诱导 i 型干扰素依赖性固有和适应性免疫。
Cancer Res. 2011 Apr 1;71(7):2488-96. doi: 10.1158/0008-5472.CAN-10-2820. Epub 2011 Feb 7.
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Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment.与CD8 + T细胞募集相关的黑色素瘤转移灶中的趋化因子表达。
Cancer Res. 2009 Apr 1;69(7):3077-85. doi: 10.1158/0008-5472.CAN-08-2281. Epub 2009 Mar 17.
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