Borda E S, Sterin-Borda L, Sterin-Speziale N, Gimeno M F, Gimeno A L
Acta Physiol Lat Am. 1978;28(6):223-33.
A histological, physiological and pharmacological study of two regions of the isolated uterine muscle of the rat., i.e., the myometrial one (a zone close to the mesometrial insertion) and the linea uteri (the antimesometrial zone) was performed. From the histological point of view the linea uteri (LU) is characterized by the presence of small bundles of longitudinal smooth muscle fibers (20 to 50), closely packed and clearly surrounded by a connective tissue, whereas in the myometrial zone (M) the smooth muscle fibers are less closely packed and the connective tissue is surrounding a greater number of them. The spontaneous oxytocin or electrically-induced initial tension developed by the LU or the M, was similar. Also the stability with time did not differ between both regions. Atropine depressed consistently the isometric developed tension of M strips, either spontaneously active or driven by oxytocin or electrical stimulation, but had no action on the mechanical activity of preparations from the LU. A pretreatment with hemicholinium also inhibited the spontaneous as well the oxytocin-induced motility of M strips, without affecting those of LU. Pharmacologic evidences suggest that acetylcholine may play a "facilitating" role in M strips for the conduction of coordinate contractions. This does not appear to be the case in the LU, which has the required characteristics to be recognized as a conductive like tissue.
对大鼠离体子宫肌两个区域，即子宫肌层区域（靠近子宫系膜附着处的一个区域）和子宫线（子宫系膜对侧区域）进行了组织学、生理学和药理学研究。从组织学角度来看，子宫线（LU）的特征是存在小束纵向平滑肌纤维（20至50条），紧密排列并被结缔组织清晰包围，而在子宫肌层区域（M），平滑肌纤维排列较疏松，结缔组织包围的数量更多。LU或M产生的自发性催产素或电诱导初始张力相似。而且两个区域随时间的稳定性也没有差异。阿托品持续抑制M条带等长收缩产生的张力，无论是自发活动还是由催产素或电刺激驱动，但对LU制剂的机械活动没有作用。用半胱氨酸预处理也抑制了M条带的自发性以及催产素诱导的运动性，而不影响LU的运动性。药理学证据表明，乙酰胆碱可能在M条带中对协调性收缩的传导起“促进”作用。在LU中似乎并非如此，LU具有被识别为传导样组织所需的特征。
