Ross Kathleen A, Brenza Timothy M, Binnebose Andrea M, Phanse Yashdeep, Kanthasamy Anumantha G, Gendelman Howard E, Salem Aliasger K, Bartholomay Lyric C, Bellaire Bryan H, Narasimhan Balaji
Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USA.
Veterinary Microbiology and Preventive Medicine, Iowa State University, 2180 Vet Med, Ames 50011, USA.
J Control Release. 2015 Dec 10;219:548-559. doi: 10.1016/j.jconrel.2015.08.039. Epub 2015 Aug 24.
Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.
复杂的生物屏障是疾病预防和治疗的主要障碍。纳米载体旨在通过增强药物穿过物理化学屏障的递送能力和改善治疗指数来克服这些障碍。本综述批判性地研究了用于各种药物递送应用的生物屏障和纳米载体载量。讨论了一系列已成功开发的纳米载体，这些纳米载体可提高组织穿透性，用于预防或治疗一系列感染性、炎症性和退行性疾病。
