Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
J Control Release. 2018 Jan 28;270:260-267. doi: 10.1016/j.jconrel.2017.12.007. Epub 2017 Dec 12.
The limited efficiency of the conventional treatment options against a variety of disorders have created demands towards the development of more efficient theranostic strategies. Advances in nanomedicine have provided promising perspectives for the treatment of hard-to-treat diseases. Application of the high-resolution imaging, multifunctional nanoparticles, and a wide variety of nanodevices for early diagnosis of disease, promoting tissue regeneration, and targeted delivery of therapeutic agents, may result in minimal side effects and improved treatment outcome. Meanwhile, a number of nanotherapeutics have shown poor efficiency that might be due to a variety of factors including the inappropriate design protocols or nonspecific drug release. Selective cell targeting and controlled drug release are the key elements which should be considered in designing the nanocarriers for targeted delivery of therapeutic agents. Linkers, the essential components incorporated in the building blocks of drug delivery systems, provide the stability, high payloads, targeted drug delivery, and controlled release, hence, they might be critically involved in the nanotherapeutic activity. In the present review, the significance of linkers in the development of effective drug delivery systems has been highlighted.
针对多种疾病，传统治疗方法的效率有限，这就要求开发更有效的治疗策略。纳米医学的进步为治疗难治性疾病提供了有前景的视角。高分辨率成像、多功能纳米颗粒和各种纳米器件的应用可实现疾病的早期诊断、促进组织再生和治疗药物的靶向递送，从而可能减少副作用并改善治疗效果。同时，许多纳米疗法的效率较差，这可能是由于多种因素造成的，包括设计方案不当或药物非特异性释放。选择性细胞靶向和控制药物释放是设计用于靶向递药的纳米载体的关键要素。连接子是药物传递系统构建块中包含的重要组成部分，可提供稳定性、高载药量、靶向药物传递和控制释放，因此，它们可能在纳米治疗活性中起着关键作用。在本综述中，突出了连接子在有效药物传递系统开发中的重要性。
