DSM Nutritional Products Ltd., R&D Human Nutrition and Health, Basel, Switzerland.
Department of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.
Int J Obes (Lond). 2016 Feb;40(2):198-205. doi: 10.1038/ijo.2015.172. Epub 2015 Aug 28.
In response to luminal food stimuli during meals, enteroendocrine cells release gastrointestinal (GI) peptides that have long been known to control secretory and motor functions of the gut, pancreas and liver. Glucagon-like peptide-1 (GLP-1) has emerged as one of the most important GI peptides because of a combination of functions not previously ascribed to any other molecule. GLP-1 potentiates glucose-induced insulin secretion, suppresses glucagon release, slows gastric emptying and may serve as a satiation signal, although the physiological status of the latter function has not been fully established yet. Here we review the available evidence for intestinal GLP-1 to fulfill a number of established empirical criteria for assessing whether a hormone inhibits eating by eliciting physiological satiation in man and rodents.
在进食时，肠内分泌细胞会对腔内的食物刺激作出反应，分泌胃肠（GI）肽，这些肽早已被证实能控制肠道、胰腺和肝脏的分泌和运动功能。胰高血糖素样肽-1（GLP-1）是最重要的 GI 肽之一，因为它具有一系列以前未归因于任何其他分子的功能。GLP-1 增强葡萄糖刺激的胰岛素分泌，抑制胰高血糖素释放，减缓胃排空，并可能作为饱食信号，尽管后者的生理状态尚未完全确定。在这里，我们回顾了肠道 GLP-1 的现有证据，以满足评估激素是否通过在人和啮齿动物中引起生理性饱腹感来抑制进食的一些既定经验标准。
