• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Peripheral mechanisms in the control of appetite and related experimental therapies in obesity.肥胖中食欲控制的外周机制及相关实验性治疗
Regul Pept. 2009 Aug 7;156(1-3):24-7. doi: 10.1016/j.regpep.2009.04.011. Epub 2009 May 3.
2
Intestinal GLP-1 and satiation: from man to rodents and back.肠降血糖素(GLP-1)与饱腹感：从人类到啮齿类动物，再回到人类。
Int J Obes (Lond). 2016 Feb;40(2):198-205. doi: 10.1038/ijo.2015.172. Epub 2015 Aug 28.
3
Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?人体胃肠道的饱腹感信号——胰高血糖素样肽-1和酪酪肽的生理作用？
Physiol Behav. 2006 Nov 30;89(4):460-4. doi: 10.1016/j.physbeh.2006.05.048. Epub 2006 Jul 7.
4
Gut hormones as peripheral anti obesity targets.肠道激素作为外周抗肥胖靶点。
Curr Drug Targets CNS Neurol Disord. 2004 Oct;3(5):379-88. doi: 10.2174/1568007043336950.
5
Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms.肠道胰高血糖素样肽-1 对摄食的影响：生理相关性和新出现的机制。
Peptides. 2020 Sep;131:170342. doi: 10.1016/j.peptides.2020.170342. Epub 2020 Jun 6.
6
The role of the stomach in the control of appetite and the secretion of satiation peptides.胃在控制食欲和分泌饱腹感肽中的作用。
Am J Physiol Endocrinol Metab. 2012 Mar 15;302(6):E666-73. doi: 10.1152/ajpendo.00457.2011. Epub 2012 Jan 3.
7
The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications.胰高血糖素样肽-1功能障碍在肥胖中的作用及潜在治疗意义。
Diabetes Obes Metab. 2014 Jan;16(1):9-21. doi: 10.1111/dom.12119. Epub 2013 May 26.
8
Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial.在健康超重和肥胖成年人中，真菌蛋白可减少能量摄入和餐后胰岛素释放，而不改变胰高血糖素样肽-1和酪酪肽浓度：一项随机对照试验。
Br J Nutr. 2016 Jul;116(2):360-74. doi: 10.1017/S0007114516001872. Epub 2016 May 20.
9
Gut hormones and appetite regulation.肠道激素与食欲调节。
Curr Opin Endocrinol Diabetes Obes. 2024 Jun 1;31(3):115-121. doi: 10.1097/MED.0000000000000859. Epub 2024 Mar 21.
10
Whey Proteins Reduce Appetite, Stimulate Anorexigenic Gastrointestinal Peptides and Improve Glucometabolic Homeostasis in Young Obese Women.乳清蛋白可降低食欲，刺激食欲抑制性胃肠道肽，并改善年轻肥胖女性的糖代谢稳态。
Nutrients. 2019 Jan 23;11(2):247. doi: 10.3390/nu11020247.

引用本文的文献

1
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease.生长分化因子15：肥胖和心血管代谢疾病的新兴生物学及治疗应用
Nat Rev Endocrinol. 2021 Oct;17(10):592-607. doi: 10.1038/s41574-021-00529-7. Epub 2021 Aug 11.
2
Vagally Mediated Gut-Brain Relationships in Appetite Control-Insights from Porcine Studies.迷走神经介导的食欲控制中的肠道-大脑关系——来自猪的研究见解。
Nutrients. 2021 Jan 30;13(2):467. doi: 10.3390/nu13020467.
3
Acute exercise and gastric emptying: a meta-analysis and implications for appetite control.急性运动与胃排空：一项荟萃分析及对食欲控制的启示
Sports Med. 2015 May;45(5):659-78. doi: 10.1007/s40279-014-0285-4.
4
Gastrointestinal morbidity in obesity.肥胖相关的胃肠道疾病。
Ann N Y Acad Sci. 2014 Apr;1311:42-56. doi: 10.1111/nyas.12385. Epub 2014 Mar 6.
5
Effect of high fat-diet and obesity on gastrointestinal motility.高脂饮食和肥胖对胃肠动力的影响。
Ann Transl Med. 2013 Jul 1;1(2):14. doi: 10.3978/j.issn.2305-5839.2012.11.01.
6
Differences in brain responses between lean and obese women to a sweetened drink.瘦女性和肥胖女性对甜味饮料的大脑反应差异。
Neurogastroenterol Motil. 2013 Jul;25(7):579-e460. doi: 10.1111/nmo.12125. Epub 2013 Apr 9.
7
Gastric electrical stimulation for the treatment of obesity: from entrainment to bezoars-a functional review.胃电刺激治疗肥胖症：从同步化到胃石症——功能综述
ISRN Gastroenterol. 2013;2013:434706. doi: 10.1155/2013/434706. Epub 2013 Feb 7.
8
Differential effect of glucose ingestion on the neural processing of food stimuli in lean and overweight adults.葡萄糖摄入对瘦人和超重成年人食物刺激神经加工的差异影响。
Hum Brain Mapp. 2014 Mar;35(3):918-28. doi: 10.1002/hbm.22223. Epub 2013 Jan 10.
9
Correlations of circulating peptide YY and ghrelin with body weight, rate of weight gain, and time required to achieve the recommended daily intake in preterm infants.循环肽 YY 和 ghrelin 与早产儿体重、体重增长率和达到推荐日摄入量所需时间的相关性。
Braz J Med Biol Res. 2012 Jul;45(7):656-64. doi: 10.1590/s0100-879x2012007500062. Epub 2012 Apr 26.
10
Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse.饮食诱导肥胖小鼠肠道传入神经饱食信号受损和迷走神经传入兴奋性增强。
J Physiol. 2011 Jun 1;589(Pt 11):2857-70. doi: 10.1113/jphysiol.2010.204594. Epub 2011 Mar 21.

本文引用的文献

1
Selection of electrical algorithms to treat obesity with intermittent vagal block using an implantable medical device.使用可植入医疗设备通过间歇性迷走神经阻滞治疗肥胖的电算法选择。
Surg Obes Relat Dis. 2009 Mar-Apr;5(2):224-9; discussion 229-30. doi: 10.1016/j.soard.2008.09.006. Epub 2008 Sep 12.
2
A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults.西布曲明对肥胖或超重成年人减肥及身体成分影响的对照药物遗传学试验。
Gastroenterology. 2008 Oct;135(4):1142-54. doi: 10.1053/j.gastro.2008.07.009. Epub 2008 Jul 16.
3
Intra-abdominal vagal blocking (VBLOC therapy): clinical results with a new implantable medical device.腹腔内迷走神经阻断（VBLOC疗法）：一种新型可植入医疗设备的临床结果
Surgery. 2008 Jun;143(6):723-31. doi: 10.1016/j.surg.2008.03.015. Epub 2008 May 9.
4
The satiety hormone peptide YY as a regulator of appetite.饱腹感激素肽YY作为食欲的调节因子。
J Clin Pathol. 2008 May;61(5):548-52. doi: 10.1136/jcp.2007.048488.
5
Mechanisms of disease: the role of gastrointestinal hormones in appetite and obesity.疾病机制：胃肠激素在食欲和肥胖中的作用
Nat Clin Pract Gastroenterol Hepatol. 2008 May;5(5):268-77. doi: 10.1038/ncpgasthep1118. Epub 2008 Apr 1.
6
Incretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.肠促胰岛素：葡萄糖依赖性促胰岛素多肽和胰高血糖素样肽-1的病理生理学及治疗意义
J Clin Pathol. 2008 Apr;61(4):401-9. doi: 10.1136/jcp.2006.043232.
7
Safety, tolerability, pharmacokinetics, and pharmacodynamic properties of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, for the treatment of obesity: results from a double-blind, placebo-controlled, single oral dose study in healthy volunteers.新型选择性大麻素-1受体反向激动剂tarantabant治疗肥胖症的安全性、耐受性、药代动力学和药效学特性：健康志愿者单次口服剂量双盲、安慰剂对照研究结果
J Clin Pharmacol. 2008 Apr;48(4):418-27. doi: 10.1177/0091270008314467. Epub 2008 Feb 7.
8
Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program.利莫那班改善超重/肥胖患者多种心血管代谢危险因素的疗效和安全性：来自肥胖症利莫那班（RIO）项目的1年汇总数据。
Diabetes Care. 2008 Feb;31 Suppl 2:S229-40. doi: 10.2337/dc08-s258.
9
The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet.内源性大麻素在胃排空调节中的作用：高脂饮食喂养小鼠的变化
Br J Pharmacol. 2008 Mar;153(6):1272-80. doi: 10.1038/sj.bjp.0707682. Epub 2008 Jan 28.
10
Effects of exenatide versus insulin analogues on weight change in subjects with type 2 diabetes: a pooled post-hoc analysis.艾塞那肽与胰岛素类似物对2型糖尿病患者体重变化的影响：一项汇总的事后分析。
Curr Med Res Opin. 2008 Mar;24(3):639-44. doi: 10.1185/030079908X260862. Epub 2008 Jan 23.

肥胖中食欲控制的外周机制及相关实验性治疗

Peripheral mechanisms in the control of appetite and related experimental therapies in obesity.

作者信息

Camilleri Michael

机构信息

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic, Rochester, Minnesota, United States.

出版信息

Regul Pept. 2009 Aug 7;156(1-3):24-7. doi: 10.1016/j.regpep.2009.04.011. Epub 2009 May 3.

DOI:10.1016/j.regpep.2009.04.011
PMID:19409936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3898935/
Abstract

The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity.

摘要

胃的功能以及肠道对食物摄入的激素反应构成了高度整合的稳态反应，以维持血糖正常和正常消化。这种内在反馈涉及迷走神经和激素机制。诸如胰高血糖素样肽-1（GLP-1）和肽YY（PYY）等重要信号在外周产生，可诱导饱腹感，还能延迟胃排空或增加胰岛素分泌。目前正在开发新的疗法来模拟或增强这些反馈机制，并控制食欲以治疗肥胖症。