Milnerowicz-Nabzdyk Ewa, Bizoń Anna
2nd Department and Clinic of Obstetrics and Gynaecology, Wroclaw Medical University, Borowska 213, 50-556 Wrocław, Poland.
Department of Biomedical and Environmental Analysis, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.
Reprod Toxicol. 2015 Dec;58:79-84. doi: 10.1016/j.reprotox.2015.08.003. Epub 2015 Aug 24.
Proper structure of the umbilical cord is important for the fetal development. We evaluated effects of toxic factors from tobacco smoke on fetal and umbilical cord morphometry. 109 women in weeks 29-40 of pregnancy (31 smokers with intrauterine growth restriction (IUGR); 28 non-smoking women with IUGR; 50 healthy pregnancies) were included. In smokers with IUGR, cotinine, cadmium and lead concentrations were significantly higher than in controls (mean 55.23ng/l; 1.52ng/ml; 14.85ng/ml vs 1.07; 0.34; 9.42) and inverse correlation between lead concentration and uncoiled umbilical cord was significant (r=-0.80). In smokers with IUGR, area of Wharton's jelly was increased compared to nonsmokers and controls. Inverse correlations occurred between cotinine and cadmium concentration and fetal percentile in smokers (r=-0.87; r=-0.87) and non-smokers (r=-0.47; r=-0.78) with IUGR. Exposure to tobacco smoke measured by cotinine, cadmium and lead concentration has an impact on fetal growth and umbilical cord morphometry and correlates with intensity of IUGR.
脐带的正常结构对胎儿发育很重要。我们评估了烟草烟雾中的有毒因素对胎儿和脐带形态测量的影响。纳入了109名怀孕29至40周的女性（31名患有宫内生长受限（IUGR）的吸烟者；28名患有IUGR的非吸烟女性；50名健康孕妇）。在患有IUGR的吸烟者中，可替宁、镉和铅的浓度显著高于对照组（平均55.23纳克/升；1.52纳克/毫升；14.85纳克/毫升，而对照组为1.07；0.34；9.42），并且铅浓度与未卷曲脐带之间的负相关显著（r = -0.80）。在患有IUGR的吸烟者中，华通胶的面积比非吸烟者和对照组增加。在患有IUGR的吸烟者（r = -0.87；r = -0.87）和非吸烟者（r = -0.47；r = -0.78）中，可替宁和镉浓度与胎儿百分位数之间存在负相关。通过可替宁、镉和铅浓度测量的烟草烟雾暴露对胎儿生长和脐带形态测量有影响，并且与IUGR的严重程度相关。
