Wakerley Benjamin R, Yuki Nobuhiro
Department of Neurology, Gloucestershire Royal Hospital, Gloucester, GL1 3NN, UK.
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Muscle Nerve. 2015 Dec;52(6):927-32. doi: 10.1002/mus.24887. Epub 2015 Sep 12.
Bifacial weakness with paresthesias (BFP) is a subtype of Guillain-Barré syndrome defined by rapidly progressive bilateral facial weakness in the absence of other cranial neuropathies, ataxia, or limb weakness. Many patients also complain of distal limb paresthesias and display diminished or absent deep tendon reflexes. BFP is a localized form of Guillain-Barré syndrome and is thought to be caused exclusively by demyelinating- rather than axonal-type neuropathy. Patients with BFP do not display anti-ganglioside IgG antibodies. Since it is rare, many physicians are unfamiliar with BFP, as bilateral facial weakness is more commonly associated with sarcoidosis, Lyme disease, or meningeal pathology. Many patients diagnosed with bilateral Bell palsy may instead have BFP. In this review, we highlight the clinical features of BFP and outline diagnostic criteria.
双侧面部无力伴感觉异常（BFP）是吉兰-巴雷综合征的一种亚型，其定义为在无其他颅神经病变、共济失调或肢体无力的情况下迅速进展的双侧面部无力。许多患者还主诉肢体远端感觉异常，并表现出深部腱反射减弱或消失。BFP是吉兰-巴雷综合征的一种局限性形式，被认为完全由脱髓鞘型而非轴索性神经病引起。BFP患者不表现出抗神经节苷脂IgG抗体。由于其罕见，许多医生对BFP并不熟悉，因为双侧面部无力更常见于结节病、莱姆病或脑膜病变。许多被诊断为双侧贝尔麻痹的患者可能实际上患有BFP。在本综述中，我们强调了BFP的临床特征并概述了诊断标准。
