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新冠相关吉兰-巴雷综合征非典型临床发作中的双侧面瘫

Bilateral Facial Paralysis in an Atypical Clinical Onset of COVID-Associated Guillain-Barre Syndrome.

作者信息

Taftaf Ahmad, Vera Cruz Claudine A, Al-Qasmi Haytham, Al-Qasmi Mohammed

机构信息

Internal Medicine, Hurley Medical Center, Flint, USA.

Neurology, Michigan State University College of Human Medicine, Flint, USA.

出版信息

Cureus. 2024 Jun 30;16(6):e63498. doi: 10.7759/cureus.63498. eCollection 2024 Jun.

DOI:10.7759/cureus.63498
PMID:39081416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11287485/
Abstract

Coronavirus disease (COVID-19) has been associated with a diverse range of extrapulmonary manifestations since its global outbreak in 2019. One of its rare complications is Guillain-Barre Syndrome (GBS), a post-infectious neurological disorder that manifests with a characteristic ascending limb paralysis. Here, we describe the atypical case of a 42-year-old African American male who developed bilateral facial paralysis within five weeks of testing positive for COVID-19. Initial diagnostic imaging and blood studies were negative for acute pathology. Albuminocytological dissociation found in a subsequent analysis of the patient's cerebrospinal fluid and his appropriate therapeutic response to intravenous immunoglobulin (IVIg) indicated GBS as the most likely diagnosis.

摘要

自2019年全球爆发以来，冠状病毒病（COVID-19）已与多种肺外表现相关联。其罕见并发症之一是吉兰-巴雷综合征（GBS），这是一种感染后神经疾病，表现为典型的上行性肢体麻痹。在此，我们描述了一例非典型病例，一名42岁非裔美国男性在COVID-19检测呈阳性后的五周内出现双侧面部麻痹。最初的诊断性影像学检查和血液研究未发现急性病变。随后对患者脑脊液的分析中发现蛋白细胞分离现象，且患者对静脉注射免疫球蛋白（IVIg）有适当的治疗反应，这表明最可能的诊断为GBS。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8001/11287485/5eafbacfe83f/cureus-0016-00000063498-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8001/11287485/4f8d10e7d571/cureus-0016-00000063498-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8001/11287485/5eafbacfe83f/cureus-0016-00000063498-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8001/11287485/4f8d10e7d571/cureus-0016-00000063498-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8001/11287485/5eafbacfe83f/cureus-0016-00000063498-i02.jpg

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Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barré syndrome.流行病学和队列研究发现 COVID-19 与吉兰-巴雷综合征之间没有关联。
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