Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Trends Neurosci. 2015 Sep;38(9):535-49. doi: 10.1016/j.tins.2015.07.006. Epub 2015 Aug 25.
Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron-astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evidence from animal models has provided a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of behavior. The development of tools for selectively controlling the temporal and spatial properties of astrocyte activity will help to consolidate our knowledge of the mechanisms underlying this involvement.
星形胶质细胞已成为信息处理中神经元的重要伙伴。在过去的二十年中，人们在理解星形胶质细胞在产生导致行为的神经元-星形胶质细胞网络输出方面的作用方面取得了重要进展。我们回顾了星形胶质细胞在认知、情绪、运动和感觉处理四个不同行为领域的参与证据。来自动物模型的越来越多的证据提供了大量数据，这些数据在很大程度上支持了星形胶质细胞对行为各个方面的直接参与。开发用于选择性控制星形胶质细胞活性的时空特性的工具将有助于巩固我们对这种参与机制的认识。
