Vitoria J C, Sebastián M J, Astigarraga I, Ariceta G, Sojo A, Rodríguez Soriano J
Departamento de Pediatría, Hospital Infantil de Cruces, Vizcaya.
An Esp Pediatr. 1989 Sep;31(3):261-4.
The incidence of cow's milk protein intolerance (CMPI) varies depending on the series. The aim of the present investigation was to determine the incidence of this disease in our population and its change over the past the years. Over the period January 1977 to December 1986, 217 patients suspected to have the disease were submitted to a cow's milk challenge test. Diagnosis was confirmed clinically and/or pathologically in 121 patients and was ruled out in 96 patients. The incidence for the whole period was 0.78 cases/1,000 alive newborn infants. However, it fell significantly over the ten years, with a maximum of 1.36/1,000 alive newborn infants in 1979 and a minimum of 0.17/1,000 alive newborn infants in 1986 (r = 0.76, p less than 0.001). We conclude that, similarly to the observation in other diseases of nutritional origin, the incidence in our population of CMPI has clearly decreased, probably as a consequence of changes in the dietary habits.
牛奶蛋白不耐受（CMPI）的发病率因不同研究系列而异。本调查的目的是确定该疾病在我们人群中的发病率及其在过去几年中的变化。在1977年1月至1986年12月期间，217名疑似患有该疾病的患者接受了牛奶激发试验。121例患者经临床和/或病理确诊，96例患者排除诊断。整个时期的发病率为0.78例/1000名存活新生儿。然而，在这十年中发病率显著下降，1979年最高为1.36/1000名存活新生儿，1986年最低为0.17/1000名存活新生儿（r = 0.76，p < 0.001）。我们得出结论，与其他营养源性疾病的观察结果类似，我们人群中CMPI的发病率明显下降，可能是饮食习惯改变的结果。
