Bacchiocchi D, Malberti R, Altamura N, Ceriani R, Colombo M, Tamburini G
Clinica Pediatrica, Ospedale San Gerardo dei Tintori, Monza.
Minerva Pediatr. 1996 Nov;48(11):499-502.
The diagnosis of cow's milk protein intolerance (CMPI) is mainly based on the response to the elimination diet and to the subsequent exposure to these proteins (challenge).
To find out whether a "formal", strictly scheduled challenge was better than a less formal test in establishing CMPI diagnosis, records were reviewed of 87 children studied in 5 Hospitals in the Milan area during the last 3 years.
The study showed that the diagnostic approach (formal vs informal challenge) did not affect the probability of confirming CMPI diagnosis (21% vs 19%). Moreover, this probability was not affected by the source of the first diagnosis (Hospital vs Family Doctor), the time elapsed between first diagnosis and challenge, and the laboratory tests performed during the challenge.
Therefore, a less strictly scheduled approach could be conveniently suggested to confirm CMPI diagnosis, at least in unselected cases.
牛奶蛋白不耐受（CMPI）的诊断主要基于对排除饮食的反应以及随后对这些蛋白质的接触（激发试验）。
为了确定在确立CMPI诊断时，“正式的”、严格安排的激发试验是否优于不太正式的测试，回顾了过去3年在米兰地区5家医院研究的87名儿童的记录。
研究表明，诊断方法（正式激发试验与非正式激发试验）并不影响确诊CMPI的概率（分别为21%和19%）。此外，这一概率不受首次诊断来源（医院与家庭医生）、首次诊断与激发试验之间的时间间隔以及激发试验期间所进行的实验室检查的影响。
因此，至少在未经过筛选的病例中，可以方便地建议采用不太严格安排的方法来确诊CMPI。
