Benigni R
Ann Ist Super Sanita. 1989;25(4):573-5.
This is a brief overview on a series of studies performed in the Istituto Superiore di Sanità (Italian National Institute of Health), all focusing on the ability of mutagenicity short-term assays of identifying genotoxic agents and predicting carcinogenicity. The analytical tools of such studies were the multivariate data analysis statistical techniques. The overall picture points to three main classes of assays, on the basis of their responses to the chemical agents in the available data bases (mainly the comparative studies). The implications for practical chemical testing and battery design are discussed.
这是对在意大利国家卫生研究院（Istituto Superiore di Sanità）进行的一系列研究的简要概述，所有这些研究都聚焦于短期致突变性试验识别基因毒性剂和预测致癌性的能力。此类研究的分析工具是多元数据分析统计技术。根据在现有数据库（主要是比较研究）中对化学试剂的反应，总体情况指向三类主要试验。文中还讨论了对实际化学测试和试验组合设计的影响。
